Results 171 to 180 of about 80,053 (258)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Cancer pain - all change please? [PDF]

Clin Med (Lond)
Yri OE, J A Laird B.
europepmc   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

The changing landscape of palliative care: a universal imperative. [PDF]

Clin Med (Lond)
Taylor A, Davies A, Saravanan P.
europepmc   +1 more source

A Scoping Review of the Emergence of Novel Synthetic Opioids in Australian Drug Markets: What Does This Mean for Harm Reduction Responses?

Drug and Alcohol Review, EarlyView.
ABSTRACT Issues Rising synthetic opioid deaths in North America, and the emergence of nitazene harms has driven concern about novel synthetic opioids (NSO) in Australia. This scoping review aimed to map what is known about NSOs in Australia. Approach Scoping review of peer‐reviewed and grey literature on NSO detections and harms.
Emmanuel Mammoliti, Suzanne Nielsen, Amanda Roxburgh   +2 more
wiley   +1 more source

Trajectories of Pain in Low-Opioid and Opioid-Based Postoperative Analgesia in Older Patients-Perioperative Clinical Study. [PDF]

J Clin Med
Kosciuczuk U, Talalaj M, Rynkiewicz-Szczepanska E.   +2 more
europepmc   +1 more source

Emergence of Medetomidine in the Unregulated Drug Supply and Its Association With Hallucinogenic Effects

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The unregulated drug supply in the United States is rapidly evolving, and veterinary tranquillisers have emerged as adulterants of concern, especially in illicitly‐manufactured fentanyl. Following the proliferation of xylazine, medetomidine, a more potent sedative, has recently appeared in multiple US states.
Adams L. Sibley, Madigan L. Bedard, Samuel Tobias, Brooke A. Chidgey, Irina G. Phillips, Alice Bell, Nabarun Dasgupta   +6 more
wiley   +1 more source

Research Trends and Knowledge Mapping of Opioid-Free Anesthesia: A Global Bibliometric Analysis. [PDF]

J Multidiscip Healthc
Guo Z, Shan Z, Wang F.
europepmc   +1 more source

Comparison of Remimazolam and Propofol for Sedation in Endoscopic Retrograde Cholangiopancreatography: A Systematic Review and Meta‐Analysis With Trial Sequential Analysis

Digestive Endoscopy, EarlyView.
This systematic review and meta‐analysis of 5 randomized controlled trials (n = 965) compares the safety profile of remimazolam versus propofol for sedation during ERCP. Remimazolam was associated with a significantly lower incidence of hypoxia, hypotension, and bradycardia.
In Jung Kim, Geun Joo Choi, Hyoung‐Chul Oh, Hyun Kang   +3 more
wiley   +1 more source