Results 21 to 30 of about 48,024 (241)

Is this opioid analgesic tolerance?

Journal of Pain and Symptom Management, 1995
Tolerance to the analgesic effect of opioids is a poorly understood phenomenon. While generally accepted to be an uncommon problem, it clearly can present major management difficulties in some patients. This case report illustrates different aspects of tolerance, describes a management approach using different opioids, and provides a focus for ...
Robin L. Fainsinger, Eduardo Bruera
openaire   +3 more sources

Clinical effectiveness and treatment satisfaction between two triple‐therapy regimens in treating neuropathic pain: A real‐world data

Ibrain, EarlyView., 2023
This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, Krupanidhi Karunanithi   +7 more
wiley   +1 more source

Predictors of shortages of opioid analgesics in the US: Are the characteristics of the drug company the missing puzzle piece?

PLoS ONE, 2021
BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio, Mahim Naveed, Enrique Seoane-Vazquez   +2 more
doaj   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Prescribing databases can be used to monitor trends in opioid analgesic prescribing in Australia

Australian and New Zealand Journal of Public Health, 2013
Objective: There has been increased use of prescription opioid analgesics in Australia in the past 20 years with increasing evidence of related problems. A number of data sources collect information about the dispensed prescribing for opioid medications,
Samantha A. Hollingworth, Martyn Symons, Mohsina Khatun, Bill Loveday, Sue Ballantyne, Wayne D. Hall, Jake M. Najman   +6 more
doaj   +1 more source

TREATMENT OF PAIN IN PEDIATRIC PATIENTS [PDF]

Journal of IMAB, 2016
The article clarifies that pain is a multidimensional phenomenon both in adults and children. The authors reviewed the literature and surveyed the clinical data on the management of pain in pediatric patients. The conclusion was made that pain management
Nikolay Yanev, Mila Vlaskovska
doaj   +1 more source

Analgesic use among the Brazilian population: Results from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM).

PLoS ONE, 2019
PurposeTo estimate the prevalence of use of analgesics in Brazil; and to characterize this use, according to sociodemographic and health-related characteristics.MethodsA cross-sectional population-based study (National Survey on Access, Use and Promotion
Tatiane da Silva Dal Pizzol, Andréia Turmina Fontanella, Maria Beatriz Cardoso Ferreira, Andréa Dâmaso Bertoldi, Rogerio Boff Borges, Sotero Serrate Mengue   +5 more
doaj   +1 more source

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

Nature Communications, 2019
Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and ...
A. Kliewer, F. Schmiedel, S. Sianati, A. Bailey, J. T. Bateman, E. S. Levitt, J. T. Williams, M. J. Christie, S. Schulz   +8 more
doaj   +1 more source

Impact of a Mandatory Prescription Drug Monitoring Program on Prescription of Opioid Analgesics by Dentists. [PDF]

PLoS ONE, 2015
Prescription Drug Monitoring Programs (PDMP) are statewide databases that collect data on prescription of controlled substances. New York State mandates prescribers to consult the PDMP registry before prescribing a controlled substance such as opioid ...
Linda Rasubala, Lavanya Pernapati, Ximena Velasquez, James Burk, Yan-Fang Ren   +4 more
doaj   +1 more source

Opioid peptide-derived analgesics [PDF]

The AAPS Journal, 2005
Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
openaire   +3 more sources