Results 51 to 60 of about 392,664 (239)

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

Journal of Neuroscience, 2015
Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery ...
Tuan Trang, R. Al-Hasani, D. Salvemini, M. Salter, H. Gutstein, C. Cahill   +5 more
semanticscholar   +1 more source

Efficacy of Local Bupivacaine Injection of Postoperative Pain in Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Regional anesthesia is effective in alleviating postoperative pain and reducing the requirement for systemic pain medications. However, optimal postoperative pain management in endoscopic sinus surgery (ESS) remains challenging.
Wiracha Leewannapasai, Navarat Tangbumrungtham, Kanokporn Sarsitthithum, Kangsadarn Tanjararak, Boonsam Roongpuvapaht   +4 more
wiley   +1 more source

Opioid Sparing Analgesics in Spine Surgery

Advances in Orthopedics, 2022
Combinations of various nonopioid analgesics have been used to decrease pain and opioid consumption postoperatively allowing for faster recovery, improved patient satisfaction, and decreased morbidity.
Logan A. Reed, Mihir Patel, Kevin Luque, Steven M. Theiss   +3 more
doaj   +1 more source

Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study was to describe prescription use of acetaminophen, a widely used analgesic and antipyretic generally considered safe during pregnancy, among pregnant women from 2000 to 2023 in Denmark with special attention towards variations following the change in over‐the‐counter (OTC) availability in 2013.
Erika B. Gram, Mette Bliddal, Sophie Pflugfelder, Peter Bjødstrup Jensen, Per Damkier   +4 more
wiley   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

The persistence of chronic opioid use in patients with inflammatory bowel disease—A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting persistent use. Methods This nationwide Danish cohort study included patients with an initial period of COU (definition: ≥3 ...
Bente Mertz Nørgård, Caroline Theilgaard Thorarinsson, Jan Nielsen, Mette Louise Andersen, Jens Kjeldsen, Torben Knudsen, Rahul S. Dalal   +6 more
wiley   +1 more source

Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database

Swiss Medical Weekly
OBJECTIVE: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.
Stephan Gut, Marlene Rauch, Manuel Haschke, Carola A. Huber, Jan Gaertner, Nadine Schur, Christoph R. Meier, Julia Spoendlin   +7 more
doaj   +1 more source

Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study

British medical journal, 2015
Objective To provide absolute and relative risk estimates of neonatal abstinence syndrome (NAS) based on duration and timing of prescription opioid use during pregnancy in the presence or absence of additional NAS risk factors of history of opioid misuse
R. Desai, K. Huybrechts, S. Hernández-Díaz, H. Mogun, E. Patorno, K. Kaltenbach, Leslie S Kerzner, B. Bateman   +7 more
semanticscholar   +1 more source

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, EarlyView.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

A new extended release formulation (OROS®) of hydromorphone in the management of pain

Therapeutics and Clinical Risk Management, 2008
Sharon M WeinsteinUniversity of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, USAAbstract: Opioid analgesics are essential in the treatment of moderate to severe cancer-related pain.
Sharon M Weinstein
doaj