Results 71 to 80 of about 74,882 (213)

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

eLife, 2021
Opioids are perhaps the most effective analgesics in medicine. However, between 1999 and 2018, over 400,000 people in the United States died from opioid overdose.
Iris Bachmutsky, Xin Paul Wei, Adelae Durand, Kevin Yackle   +3 more
doaj   +1 more source

A Prospective Randomized Study Analyzing Preoperative Opioid Counseling in Pain Management After Carpal Tunnel Release Surgery. [PDF]

, 2017
PURPOSE: Prescription opioid misuse has become increasingly prevalent in the United States. Preoperative opioid counseling has been proposed to decrease opioid consumption after surgery.
Alter, Todd H., Ilyas, Asif M
core   +3 more sources

Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]

arXiv, 2020
Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv  

Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents [PDF]

, 2014
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients.
A Kretzschmar, A Mañas, A Wardley, AT Stopeck, C Langer, C Logothetis, Charles S. Cleeland, CI Ripamonti, CJ Logothetis, CS Cleeland, CS Cleeland, D Henry, D Patrick, DH Henry, DL Patrick, Donald L. Patrick, DS Ernst, E Basch, E Chow, F Saad, F Saad, G Apolone, G Cartenì, G Storto, GN Hortobagyi, GN Hortobagyi, HI Scher, JJ Body, JJ Body, K Altundag, K Fizazi, K Harris, Katarina Öhrling, KC Chung, KP Weinfurt, KP Weinfurt, L Atahan, L Costa, L Fallowfield, Lesley Fallowfield, LS Matza, LS Rosen, LS Rosen, LS Rosen, M Huisman, M Martin, M Tomblyn, MG Lam, MJ Fisch, N Kohno, N Takeda, P Hoskin, P Hoskin, R Moos von, R Moos von, Rachel Wei, RE Coleman, RE Coleman, RE Coleman, RH Dworkin, RL Theriault, Roger von Moos, S Deandrea, S Nilsson, S Vadhan-Raj, SD Mathias, T Kijima, V Vassiliou, V Vassiliou, Yi Qian   +69 more
core   +1 more source

Opioid analgesics [PDF]

The Lancet, 2016
Silvia, Allende-Pérez, Alfredo, Covarrubias-Gomez   +1 more
openaire   +5 more sources

Machine-learning Analysis of Opioid Use Disorder Informed by MOR, DOR, KOR, NOR and ZOR-Based Interactome Networks [PDF]

arXiv, 2023
Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and ...
arxiv  

A new extended release formulation (OROS®) of hydromorphone in the management of pain

Therapeutics and Clinical Risk Management, 2008
Sharon M WeinsteinUniversity of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, USAAbstract: Opioid analgesics are essential in the treatment of moderate to severe cancer-related pain.
Sharon M Weinstein
doaj  

Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database

Swiss Medical Weekly
OBJECTIVE: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.
Stephan Gut, Marlene Rauch, Manuel Haschke, Carola A. Huber, Jan Gaertner, Nadine Schur, Christoph R. Meier, Julia Spoendlin   +7 more
doaj   +1 more source

Infiltrative analgesia of the skin flap in children with craniosynostosis after reconstructive surgery on skull bones

Вестник анестезиологии и реаниматологии, 2020
The objective of the study is to evaluate the effectiveness of analgesia by infiltration of the skin flap with local anesthetic in children with craniosynostosis after reconstructive surgery.Materials and subjects.
O. N. Pulkina, V. P. Ivanov, V. I. Gurskaya, E. V. Parshin   +3 more
doaj   +1 more source

Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learning [PDF]

arXiv, 2020
The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical interventions to reduce the risk of OUD.
arxiv