Results 231 to 240 of about 120,626 (262)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Loneliness and social isolation as predictors of pain medication use transitions in older adults. [PDF]

Sci Rep
Piot A, Fancourt D, Bloomberg M, Steptoe A, Bu F.   +4 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Total Antioxidant Capacity and Total Oxidative Capacity in Multi-Modal Opioid-Based Therapy for Non-Cancer Pain: Analysis of Redox Status. [PDF]

Curr Issues Mol Biol
Kosciuczuk U, Jakubow P, Talalaj M, Grabowska K.   +3 more
europepmc   +1 more source

Efficacy of a virtual reality headset in the management of severe pain during a vaso‐occlusive crisis: A single‐centre study in adults with sickle cell disease

British Journal of Haematology, EarlyView.
Geoffrey Cheminet, Anne Corbasson, Kinda Al Kudsee, Marie Charmettan, Carole Barthélémy, Walid Namaoui, Djamal Khimoud, Jean‐Benoît Arlet   +7 more
wiley   +1 more source

Changing Worlds, Changing Drug Markets. [PDF]

Nordisk Alkohol Nark
Hellman M.
europepmc   +1 more source

Evolving Paradigms in Cancer Pain Management: From Opioid-Centric Care to Multimodal and Personalized Strategies. [PDF]

Cancers (Basel)
Barrios I, Thomas SA, Hernandez YL, Pagan A, Munoz E, Cespedes K, Aggarwal S.   +6 more
europepmc   +1 more source

Acute Pain During Intensive Care: Prevalence, Predisposing Factors and Pain Trajectories. A Prospective Multicenter Observational Study. [PDF]

Acta Anaesthesiol Scand
Wlodarczyk-Abou Elseoud AE, Kalliomäki ML, Mäkinen O, Laukkanen A, Bäcklund M, Lääperi M, Hamunen K, Kuivalainen AM.   +7 more
europepmc   +1 more source

Intrathecal Ziconotide Long-Term Management in Chronic Postamputation Pain. [PDF]

Case Rep Anesthesiol
Mateos RG, Tous NC, Katati M, Carrasco BL, García MAS.   +4 more
europepmc   +1 more source