Results 21 to 30 of about 52,277 (300)
SAGE Open Medicine, 2019 Objectives: Pain is considered the most common and debilitating symptom reported by patients affected by cancer, and opioids are at the front line for its effective management.
Andreas Charalambous +3 more
doaj +1 more source
PAIN Reports, 2018 . Introduction:. Cognitive performance and inflammation are altered in people with chronic low back pain (CLBP). Yet, the magnitude of these changes has been unclear because of the potential influence of opioid analgesics. Objectives:.
Georgia C. Richards +6 more
doaj +1 more source
Acta Orthopaedica, 2022 Background and purpose: Total hip (THA) and knee (TKA) arthroplasty are effective pain treatment in osteoarthritis; however, there are patients with long-term pain and in need of analgesics.
Ville Turppo +4 more
doaj +1 more source
The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]
, 2015 The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
Pergolizzi, Joseph +7 more
core +1 more source
PLoS ONE, 2021 BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio +2 more
doaj +1 more source
Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
openaire +2 more sources
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
core +1 more source
Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis [PDF]
, 2023 GOALS/BACKGROUND: Pain is common among cirrhosis patients, particularly those hospitalized with acute illness. Managing pain in this population is challenging due to concern for adverse events and lack of guidelines for analgesic use.
Rubin, Jessica B +4 more
core +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source