TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier
Marine Drugs, 2019 As the first in a new class of non-opioid drugs, ω-Conotoxin MVIIA was approved for the management of severe chronic pains in patients who are unresponsive to opioid therapy.
Shuo Yu +8 more
doaj +1 more source
Analgesic effect of ropivacaine with fentanyl in comparison with ropivacaine alone for continuous femoral nerve block after knee replacement arthroplasty: a prospective, randomized, double-blinded study [PDF]
, 2020 Gunn Hee Kim +10 more
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Advanced Science, EarlyView.This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang +10 more
wiley +1 more source
A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities [PDF]
, 2017 Ping Wu +7 more
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Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy
Advanced Science, EarlyView.A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen +8 more
wiley +1 more source
Healthcare professionals’ views and perceptions of analgesic and antipyretic use in paediatric patients in four major Saudi hospitals [PDF]
, 2020 Mansour Tobaiqy +4 more
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Advanced Science, EarlyView.This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi +11 more
wiley +1 more source
Attitudinal Barriers to Effective Cancer Pain Management
حیات, 2012 Background & Aim: Pain can detrimentally affect physical functioning, psychological well-being and social interaction. Various attitudinal factors may be associated with inadequate pain control.
Tahereh Najafi Ghezeljeh +1 more
doaj
Analgesic effects of parecoxib following total abdominal hysterectomy † †Declaration of interest. The authors are grateful to Pharmacia for an educational grant for this trial. [PDF]
, 2003 Alexander Ng +2 more
openalex +1 more source