Results 121 to 130 of about 354,000 (376)

Topical analgesics for neuropathic pain: Preclinical exploration, clinical validation, future development

European Journal of Pain, 2014
Topical analgesics applied locally to skin or to specialized compartments modify pain by actions on sensory nerve endings and/or adjacent cellular elements.
J. Sawynok
semanticscholar   +1 more source

Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

Advanced Science, EarlyView.
This work develops a 3D label‐free photoacoustic/super‐resolution ultrasound imaging system as a comprehensive non‐invasive tool for acute kidney injury (AKI) study. This technique visualizes the intricate structure of renal microvessels and provides critical physiological insights, including renal hemodynamics and oxygenation.
Shensheng Zhao, Xingxing Zhang, Keith Bailey, Sathvik Pai, Yang Zhao, Yun‐Sheng Chen   +5 more
wiley   +1 more source

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

Dentistry Journal, 2019
One of the most common post-operative complications of tooth extraction is pain. Oral analgesics, namely loxoprofen sodium and diclofenac potassium, are often prescribed; however, the efficacy of these drugs irrespective of gender and type of extraction ...
Ibrahim Nourwali, Arwa Namnakani, Majd Almutairi, Anas Alaufi, Yasser Aljohani, Saba Kassim   +5 more
doaj   +1 more source

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Advanced Science, EarlyView.
This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas   +4 more
wiley   +1 more source

Analgesic strategies

South African Family Practice, 2014
No abstract available.
openaire   +3 more sources

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Anesthesia and perioperative pain management during cardiac electronic device implantation

Journal of Pain Research, 2017
Marina Biocic,1 Dijana Vidosevic,2 Matija Boric,1,3 Teo Boric,4 Lovel Giunio,2 Damir Fabijanic,2 Livia Puljak1,5 1Laboratory for Pain Research, University of Split School of Medicine, 2Department of Cardiology, 3Department of Abdominal Surgery ...
Biocic M, Vidosevic D, Boric M, Boric T, Giunio L, Fabijanic D, Puljak L   +6 more
doaj  

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

Advanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman, Taron Bashar, Alex Burton, David Marshall Clausen, Prashant Gupta, Drew K. Wolf, Jakayla Folarin‐Hines, Maria Payne, John A Rogers, Kathleen W. Meacham, Robert W. Gereau, Philipp Gutruf   +11 more
wiley   +1 more source

Multilineage-differentiating stress-enduring cells alleviate neuropathic pain in mice by secreting TGF-b and IL-10 [PDF]

arXiv
Neuropathic pain is a chronic condition characterized by damage to and dysfunction of the peripheral or central nervous system. There are currently no effective treatment options available for neuropathic pain, and existing drugs often provide only temporary relief with potential side effects.
arxiv  

ANIMAL EXPERIMENTATION IN STUDYING ADDICTION TO THE NEWER SYNTHETIC ANALGESICS [PDF]

, 1948
M.H. SEEVERS
openalex   +1 more source