Results 101 to 110 of about 41,207 (254)

Regular use of traditional analgesics predicts major coronary events: A cohort study

, 2008
Mikko Haara1, Markku Heliövaara2, Jari PA Arokoski3, Paul Knekt2, Pirjo Manninen4, Arpo Aromaa2, Antti Reunanen2, Olli Impivaara2, Heikki Kröger51Bone and Cartilage Research Unit (BCRU), University of Kuopio, Kuopio, Finland; 2National ...
Paul Knekt, et al, Markku Heliövaara, Mikko Haara, Jari PA Arokoski, Pirjo Manninen   +5 more
core  

TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier

Marine Drugs, 2019
As the first in a new class of non-opioid drugs, ω-Conotoxin MVIIA was approved for the management of severe chronic pains in patients who are unresponsive to opioid therapy.
Shuo Yu, Yumeng Li, Jinqin Chen, Yue Zhang, Xinling Tao, Qiuyun Dai, Yutian Wang, Shupeng Li, Mingxin Dong   +8 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Medical Misinformation and Quality of Public Video Content on Cannabis for Chronic Pain Management: A Cross-Sectional Analysis of the YouTube Platform

Journal of Pain Research
Bright Etumuse,1 Majesty Greer,2 Jane Onyemachi,1 Youshaa El-Abed,3 Sai Kamma,1 Jay D Shah,4 Henry Tuan Tran,1 Nasir Hussain,5 Thomas P Pittelkow,6 Ryan S D’Souza6 1University of Texas Medical Branch School of Medicine, Galveston, TX, USA; 2Howard ...
Etumuse B, Greer M, Onyemachi J, El-Abed Y, Kamma S, Shah JD, Tran HT, Hussain N, Pittelkow TP, D’Souza RS   +9 more
doaj  

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

National consumption of opioid and nonopioid analgesics in Croatia: 2007–2013

, 2015
Darko Krnic,1 Andrea Anic-Matic,2 Svjetlana Dosenovic,2 Pero Draganic,1 Sasa Zezelic,1 Livia Puljak2 1Agency for Medicinal Products and Medical Devices, Zagreb, 2Laboratory for Pain Research, School of Medicine, University of Split, Split, Croatia ...
Anic-Matic A, Dosenovic S, Zezelic S, Puljak L, Krnic D, Draganic P   +5 more
core  

An investigation into the prescribing of analgesics [PDF]

, 1996
CITATION: Truter, I. & Kotze, T. J. v. W. 1996. An investigation into the prescribing of analgesics. South African Medical Journal, 86(11):1394-1397.The original publication is available at http://www.samj.org.zaTo investigate the prescribing of ...
Truter, I., Kotze, T. J. Van Wyk
core  

Opioidni analgetici [PDF]

Vojnosanitetski Pregled, 2004
Vučković Sonja M., Prostran Milica Š., Ivanović Milovan D., Todorović Zoran M., Stojanović Radan M., Nešić Zorica I., Matić Ivana, Milovanović Slobodan R.   +7 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Attitudinal Barriers to Effective Cancer Pain Management

حیات, 2012
Background & Aim: Pain can detrimentally affect physical functioning, psychological well-being and social interaction. Various attitudinal factors may be associated with inadequate pain control.
Tahereh Najafi Ghezeljeh, Agha Fatemeh Hosseini   +1 more
doaj