Results 91 to 100 of about 175,254 (314)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

open access: yesAdvanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu   +14 more
wiley   +1 more source

Increase in fatal poisonings involving opioid analgesics in the United States, 1999-2006 [PDF]

open access: yes
"KEY FINDINGS: Data from the National Vital Statistics System Mortality File. From 1999 through 2006, the number of fatal poisonings involving opioid analgesics more than tripled from 4,000 to 13,800 deaths.

core  

The effect of local/topical analgesics on incisional pain in a pig model [PDF]

open access: yes, 2017
David Castel,1 Itai Sabbag,2 Sigal Meilin3 1The Neufeld Cardiac Research Institute, Sheba Medical Centre, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, 2Lahav Research Institute, Kibutz Lahav, Negev, 3Neurology R&D Division, MD ...
Castel D, Sabbag I, Meilin S
core  

Adjuvant Analgesics in Cancer Pain: A Review [PDF]

open access: yes, 2011
Adjuvant analgesics (co-analgesics) are medications whose primary indication is the management of a medical condition with secondary effects of analgesia.
Raj Mitra, Stephanie Jones
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun   +7 more
wiley   +1 more source

Narcotic Analgesics: OPIOIDS [PDF]

open access: yes, 2019
Opioids are morphine-like analgesics used for the management of severe pain, such as acute pain and cancer pain. They are mostly preferred in cases of acute and chronic severe pain.
Erbaba, Hülya
core  

Adjuvant analgesics in acute pain [PDF]

open access: yes, 2011
Introduction: Despite its central role in acute pain management, the exclusive use of opioids has been challenged recently in view of its immediate and long-term side effects.
Lui, F   +3 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

open access: yesAdvanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan   +24 more
wiley   +1 more source

Use of non-prescription analgesics and male reproductive function [PDF]

open access: yes, 2017
We studied the association between intake of non-prescription analgesics and semen quality and male reproductive hormone levels in a cross-sectional study among 1493 men.
Ramlau-Hansen, C. H.   +9 more
core   +1 more source

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