Results 71 to 80 of about 247,850 (306)

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Predictors of Opioid Prescription Among a Sample of Patients with Acute Musculoskeletal Pain at a Tertiary Care Hospital in Saudi Arabia

Journal of Pain Research, 2020
Yazed AlRuthia,1,2 Hawazin Alhazzani,1 Ghaida Alhindi,1 Maryam Alarfaj,1 Lama Almutairi,3 Miteb Alanazi,4 Khaulah Alokili,1 Nouf Alanazi,1 Faris Alodaibi,5 Monira Alwhaibi,1 Adel S Bashatah,6 Yousif Asiri,1 Hisham Alsanawi7 1Department of Clinical ...
AlRuthia Y, Alhazzani H, Alhindi G, Alarfaj M, Almutairi L, Alanazi M, Alokili K, Alanazi N, Alodaibi F, Alwhaibi M, Bashatah AS, Asiri Y, Alsanawi H   +12 more
doaj  

Digital Analgesic Comprising a Second-Generation Digital Health System: Increasing Effectiveness by Optimizing the Dosing and Minimizing Side Effects

Journal of Pain Research, 2022
Henny Azmanov,* Areej Bayatra,* Yaron Ilan Hebrew University, Faculty of Medicine, Hadassah Medical Center, Jerusalem, Israel*These authors contributed equally to this workCorrespondence: Yaron Ilan, Department of Medicine, Hebrew University,
Azmanov H, Bayatra A, Ilan Y
doaj  

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Postoperative pain management in emergency surgeries: A one-year survey on perception and satisfaction among surgical patients

Nigerian Journal of Surgery, 2020
Background: Postoperative pain varies from an individual to individual. It also varies with types and extent of surgery. In general, postoperative pain is inadequately managed in most centers worldwide, especially in developing countries. Therefore, this
AbdulGhaffar A Yunus, Euphemia M Ugwu, Yunusa Ali, Ganiyat Olagunju   +3 more
doaj   +1 more source

Combination of magnesium sulphate and ropivacaine epidural analgesia for hip arthroplasty in dogs [PDF]

, 2017
The aim of this study was to determine whether lumbosacral epidural administration of magnesium sulphate added to ropivacaine prolongs and improves perioperative analgesia, without adverse effects on motor block duration or hind limb neurological ...
Adami, C, Lardonea, E, Peironea, B
core   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin) : study protocol for a randomized controlled trial [PDF]

, 2014
Peer reviewedPublisher ...
Anson, Ken, Burr, Jennifer, Kilonzo, Mary, Lam, Thomas, MacLennan, Graeme Stewart, McClinton, Sam, McDonald, Alison, McPherson, Gladys, N'Dow, James, Pickard, Robert, Starr, Kathryn, SUSPEND Study Group, Thomas, Ruth   +12 more
core   +2 more sources

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source