Results 41 to 50 of about 886,439 (248)

Analog computation using quantum-dot cell network

open access: yes, 2001
A novel analog-computation system using a quantum-dot cell network is proposed to solve complex problems. Analog computation is a promising method for solving a mathematical problem by using a physical system analogous to the problem. We designed a novel
Wu NJ   +3 more
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Characterizing the firing properties of an adaptive analog VLSI neuron [PDF]

open access: yes, 2004
Ben Dayan Rubin D, Chicca E, Indiveri G. Characterizing the firing properties of an adaptive analog VLSI neuron. Biologically Inspired Approaches to Advanced Information Technology.
Ben Dayan Rubin, D.   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Analog and symbolic computation through the Koopman framework

open access: yesJournal of Physics: Complexity
We develop a Koopman operator framework for studying the computational structure of dynamical systems. Specifically, we show that the resolvent of the Koopman operator provides a natural abstraction of halting, yielding a ‘Koopman halting problem’ that ...
Francesco Caravelli   +1 more
doaj   +1 more source

Reconfigurable Computation in Spiking Neural Networks

open access: yesIEEE Access, 2020
The computation of rank ordering plays a fundamental role in cognitive tasks and offers a basic building block for computing arbitrary digital functions.
Fabio Schittler Neves, Marc Timme
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Une généralisation du critère de Boulier–Buchberger pour le calcul des ensembles caractéristiques d’idéaux différentiels

open access: yesComptes Rendus. Mathématique, 2022
We generalize the analog of Buchberger’s first criterion, stated by Boulier et al., for detecting useless S-polynomials reductions in the computation of characteristic sets of differential ideals.
Hashemi, Amir, Ollivier, François
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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