Results 91 to 100 of about 4,616,861 (293)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Sparse Signal Acquisition via Compressed Sensing and Principal Component Analysis

Measurement Science Review, 2018
This paper presents a way of acquiring a sparse signal by taking only a limited number of samples; sampling and compression are performed in one step by the analog to information conversion.
Andráš Imrich, Dolinský Pavol, Michaeli Linus, Šaliga Ján   +3 more
doaj   +1 more source

Recent Advances in Real-Time Musical Effects, Synthesis, and Virtual Analog Models [PDF]

, 2011
This paper reviews some of the recent advances in real-time musical effects processing and synthesis. The main emphasis is on virtual analog modeling, specifically digital emulation of vintage delay and reverberation effects, tube amplifiers, and voltage-
Victor Lazzarini, Federico Fontana, Vesa Välimäki, Fontana, Federico, Välimäki, Vesa, Jonathan S. Abel, Lazzarini, Victor, Jyri Pakarinen, Vesa Välimäki, Abel, Jonathan, Abel, Jonathan S., Jonathan S Abel, Pakarinen, Jyri   +12 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Signal Seperation Using Multi-rate Signal Processing

, 2001
In signal separation and channel equalisation, a short delay spread channel can result in high complexity receiver filters. The computational complexity of estimating these filters can be reduced by using multi-rate technique.
Dam, Hai, Dam, Hai Huyen, Nordholm, Sven, Nordberg, Jörgen   +3 more
core  

An Analytical MOS Transistor Model Valid in All Regions of Operation and Dedicated to Low-Voltage and Low-Current Applications

LSI2special issue of the Analog Integrated Circuits and Signal Processing Journal on Low-Voltage and Low-Power ...
Vittoz, E. A., Krummenacher, F., Enz, C. C.   +2 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Neuromorphic Denoising with Fully Analog Memristive In‐Memory Computing

Advanced Intelligent Systems
Analog compute‐in‐memory (CIM) technology utilizes the physical characteristics of memory devices to cancel the repeated data movement between memory and processors.
Daijing Shi, Teng Zhang, Yuqi Li, Yaoyu Tao, Bonan Yan, Yuchao Yang   +5 more
doaj   +1 more source