Results 71 to 80 of about 4,616,861 (293)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Unbiased Injection of Signal-Dependent Noise in Variance-Stabilized Range
, 2016 <p>The design, optimization, and validation of many image processing or image-based analysis systems often requires testing of the system performance over a dataset of images corrupted by noise at different signal-to-noise ratio regimes.
Vieira, Marcelo +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Adaptive Sensor Response Correction Using Analog Filter Compatible with Digital Technology
, 2005 An analog adaptive filter for response correction of a load cell sensor is presented. The filter employs only transistors and therefore it can be integrated using digital CMOS technology, which is suitable for System-on-Chip applications.
White, Neil M. +2 more
core +1 more source
IIR array processing based fast adaptive null steering algorithm using shift-invariant subarrays
, 2012 This paper presents and investigates a fast adaptive null steering system employing infinite impulse response (IIR) array processing. The new algorithm is of considerable interest in communications where the desired signal is weak compared with the ...
Leng, S., Ser, Wee
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
A Current-mode Based Field-programmable Analog Array For Signal Processing Applications
, 2015 This paper presents a new approach to develop Field Programmable Analog Arrays (FPAAs), 1 which avoids excessive number of programming elements in the signal path, thus enhancing the performance.
Oki N. +4 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Design of optical fiber transmission system of analog signal under microwave drying coal environment
Gong-kuang zidonghua, 2015 Under high-power microwave environment, transmission of electrical signals could easily be affected by electromagnetic interference and lead to loss of transmission accuracy.
GAO Xianru, ZHOU Xinzhi
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source