Results 111 to 120 of about 4,799,373 (254)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analog parallel processor for broadband multifunctional integrated system based on silicon photonic platform

Light: Science & Applications
Sharing the hardware platform between diverse information systems to establish full cooperation among different functionalities has attracted substantial attention.
Na Qian, Defu Zhou, Haowen Shu, Ming Zhang, Xingjun Wang, Daoxin Dai, Xiao Deng, Weiwen Zou   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Application of lossless signal transmission technology in piano timbre recognition

Nonlinear Engineering
In a timbre recognition system, the representation of functional sounds is the foundation of timbre frequency recognition correlation analysis and is crucial for the overall performance of the system.
Li Lin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Survey of Analog Computing for Domain-Specific Accelerators

Analog computing has re-emerged as a powerful tool for solving complex problems in various domains due to its energy efficiency and inherent parallelism.
Soumyajit Mandal, Asif Uddin, Arjuna Madanayake, Leonid Belostotski   +3 more
core   +1 more source

IQ-imbalance and its compensation for non-ideal analog receivers comprising frequency-selective components [PDF]

Advances in Radio Science, 2006
Within current implementations of mobile terminals, more and more analog components are replaced by appropriate digital processing. On the one hand, the analog front-ends become less complex.
M. Mailand, R. Richter, H.-J. Jentschel
doaj  

Real-time gap-free dynamic waveform spectral analysis with nanosecond resolutions through analog signal processing. [PDF]

Nat Commun, 2020
Konatham SR, Maram R, Romero Cortés L, Chang JH, Rusch L, LaRochelle S, Guillet de Chatellus H, Azaña J.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A NEW CURRENT TUNABLE CURRENT INPUT CURRENT OUTPUT BIQUAD USING CFTAS [PDF]

Journal of Engineering Science and Technology, 2017
A new current-tunable current input current output universal biquad circuit synthesized with three current follower trans-conductance amplifiers (CFTAs) and two grounded capacitors is presented in this paper. The proposed circuit simultaneously, realizes
S. V. SINGH, R. S. TOMAR, D. S. CHAUHAN
doaj