Results 21 to 30 of about 224 (219)

Feeling Like a Bat: A Critique of Thomas Nagel

Relations
According to Thomas Nagel’s thought, human beings are incapable of subjectively experiencing what a bat experiences. The only possibilities outlined by the philosopher are: (1) the objective analysis of ethological expressions, that is, the description ...
Roberto Marchesini
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Biskoppen og asketen

Religionsvidenskabeligt Tidsskrift, 2018
ENGELSK SUMMARY: The sculptures on the altarpiece of Aarhus Cathedral are a good example of 'analogism', an understanding of reality (an 'ontology') that presents an ideal reality as a harmonious order.
Hans J. Lundager Jensen
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Helgener over det hele: Polymorf middelalderkristendom i Vor Frue Kirke, Skive

Religionsvidenskabeligt Tidsskrift, 2019
English ABSTRACT: Drawing on iconographic material in the form of a decoration of church frescoes from the year 1522 in the medieval parish church Vor Frue Kirke in Skive (in Jutland) this article examines the Christian cult and mythology of saints in ...
Nikolaj Skou Haritopoulos
doaj   +1 more source

The Stress Analogy [PDF]

Schizophrenia Bulletin, 1987
The author calls attention to the advantages of using the engineering meaning of stress and strain when applying these terms to describe the effects of social and physical forces on people. Such an analogy opens up the possibility of measuring the amount of damage from excess stresses existing in people, as well as estimating their limits and remaining
openaire   +2 more sources

Rhetoric and Analogies [PDF]

SSRN Electronic Journal, 2013
The art of rhetoric may be defined as changing other people's minds (opinions, beliefs) without providing them new information. One technique heavily used by rhetoric employs analogies. Using analogies, one may draw the listener's attention to similarities between cases and to re-organize existing information in a way that highlights certain ...
Enriqueta Aragones, Itzhak Gilboa, Andrew Postlewaite, David Schmeidler   +3 more
openaire   +6 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source