Results 61 to 70 of about 83,154 (265)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

eLife, 2015
An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process.
Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial   +4 more
doaj   +1 more source

Conversion from linear to circular polarization in FPGA

, 2010
Context: Radio astronomical receivers are now expanding their frequency range to cover large (octave) fractional bandwidths for sensitivity and spectral flexibility, which makes the design of good analogue circular polarizers challenging.
Das, Koyel, Keller, R., Roy, A. L., Tuccari, G.   +3 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A capacitive mismatch calibration method for SAR ADCs based on TDC

Electronics Letters
The capacitance mismatch problem limits the accuracy improvement of high‐precision SAR ADCs (Successive Approximation Register Analog‐to‐Digital Converters).
Qing Shen, Xin Wang, Mei Jiang, Junxian Chen, Xinhui He, Huanhuan Zhou   +5 more
doaj   +1 more source

Computer Aided Analysis of Turbine Blade Vibration Test Data

Measurement + Control, 1973
A pilot system has been developed which automatically scans and evaluates experimental vibration data obtained from a test rig replica of a bladed wheel of a turbine in service. High vibration amplitude signals are selected for further analysis.
F. L. N-Nagy, S. R. Taylor
doaj   +1 more source

Digitizing UK analogue magnetogram records from large geomagnetic storms of the past two centuries

Geoscience Data Journal, 2023
Continuous geomagnetic records of the strength and direction of the Earth's field at the surface extend back to the 1840s. Over the past two centuries, eight observatories have existed in the United Kingdom, which measured the daily field variations ...
Ciaran D. Beggan, Eliot Eaton, Eleanor Maume, Ellen Clarke, John Williamson, Thomas Humphries   +5 more
doaj   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Time‐interleaving design of error‐feedback sigma‐delta modulators with infinite impulse response noise transfer function

IET Circuits, Devices and Systems, 2021
Transceivers built to modern communication standards tend to be as digital as possible, including the radio‐frequency stages. This forces the digital‐to‐analogue converters (DACs) in the transmitter section to have a large bandwidth.
Francisco Colodro, Juana Maria Martinez‐Heredia, Jose L. Mora, Antonio Torralba   +3 more
doaj   +1 more source