Results 41 to 50 of about 106,149 (275)
Twice‐input variable‐resolution single‐side switching scheme without reset energy for SAR ADC
Electronics LettersA twice‐input variable‐resolution single‐side switching scheme without reset energy is proposed for successive approximation register (SAR) analogue‐to‐digital converters (ADCs).
Bin Tang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Improved method of digital/analogue and analogue/digital conversion
Electronics Letters, 1983 The letter describes a method of rapidly interpolating between the levels of a DAC. Having inherent monotonicity, the method offers major advantages in analogue/digital and digital/analogue conversion in a certain important range of applications.
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes
eLife, 2015 An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process.
Roberto Villaseñor +4 more
doaj +1 more source
Testing high resolution SD ADC’s by using the noise transfer function [PDF]
, 2004 A new solution to improve the testability of high resolution SD Analogue to Digital Converters (SD ADC’s) using the quantizer input as test node is described.
Richardson, Andrew, De-Venuto, Daniela
core
Whisper-to-speech conversion using restricted Boltzmann machine arrays [PDF]
, 2014 Whispers are a natural vocal communication mechanism, in which vocal cords do not vibrate normally. Lack of glottal-induced pitch leads to low energy, and an inherent noise-like spectral distribution reduces intelligibility.
Li, Jing-jie +3 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source