Results 51 to 60 of about 20,345 (263)
Materials & Design, 2021 This study introduces a fused filament fabrication (FFF) process for manufacturing complex-structured asteroid analogue objects to be applied in tomographic microwave radar measurements and inversion studies. We describe an approach to control the volume
Liisa-Ida Sorsa +5 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis
Nature Communications, 2016 Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate
Robert M. Vogel +2 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
VolcanicaModelling pyroclastic density currents (PDCs) is a challenging yet essential element of hazard assessment. PDCs are unpredictable and internal processes are often difficult to measure directly.
Nemi Walding +5 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Analogue modelling an array of the FitzHugh–Nagumo oscillators
Nonlinear Analysis, 2012 The purpose of the paper is to show that analogue electronic modelling is an extremely fast technique compared to conventional digital computing, especially when solving large sets of coupled nonlinear differential equations.
Elena Tamaševičiūtė +1 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Analogue modelling of the initiation of subduction [PDF]
Geophysical Journal International, 2005 SUMMARY We report the results of experiments on the initiation of subduction, using stratified analogue models in a large centrifuge, where the experiments are driven only by the enhanced gravity of the centrifuge without the effect of external lateral stresses. The scaled density of the stratified components resembles that of the asthenosphere and the
Yossi Mart +5 more
openaire +1 more source