Results 51 to 60 of about 72,747,221 (383)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

January 2011 [PDF]

open access: yes, 2011
https://nsuworks.nova.edu/shss_dcar/1004/thumbnail ...
Department of Conflict Analysis and Resolution
core   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Justice Data Base Directory [PDF]

open access: yes, 1992
The Justice Data Base Directory was originally published in 1988 with an introduction, 8 chapters describing Alaska justice agencies and their data holdings, and an index. It was published in looseleaf notebook format for easy updating. Four updates were
Alaska Justice Statistical Analysis Unit   +1 more
core  

Analysis under analysis [PDF]

open access: yesNature, 1989
Principal Component Analysis in Meteorology and Oceanography. By Rudolph W. Preisendorfer. Posthumously compiled and edited by Curtis D. Mobley. Elsevier: 1988. Pp.425. Dfl.210.
openaire   +1 more source

Integrative analysis of 111 reference human epigenomes

open access: yesNature, 2015
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest
R. Consortium   +95 more
semanticscholar   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

Analysis of 2021 pacific salmon fishing season

open access: yesИзвестия ТИНРО, 2022
Analysis of 2021 Pacific salmon fishing season in the Far East of Russia is presented. It is based on data obtained from the Department of Anadromous Fish of Russia and the Far Eastern branches of the FSBSI «VNIRO», as well as the Far Eastern Territorial
S. L. Marchenko
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

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