Results 101 to 110 of about 174,873,121 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Hybrid Newton-like Inverse Free Algorithms for Solving Nonlinear Equations

Iterative algorithms requiring the computationally expensive in general inversion of linear operators are difficult to implement. This is the reason why hybrid Newton-like algorithms without inverses are developed in this paper to solve Banach space ...
Argyros, Christopher I., Ioannis K. Argyros, George, Santhosh, Christopher I. Argyros, Argyros, Ioannis K., Samundra Regmi, Santhosh George, Regmi, Samundra   +7 more
core   +1 more source

08201 Abstracts Collection – Design and Analysis of Randomized and Approximation Algorithms [PDF]

, 2008
From 11.05.08 to 16.05.08, the Dagstuhl Seminar 08201 ``Design and Analysis of Randomized and Approximation Algorithms'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Dyer, Martin E., Jerrum, Mark, Karpinski, Marek   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Differentially Private Analysis of Graphs

, 2016
Presented on November 7, 2016 at 11:00 a.m. in the Klaus Advanced Computing Building, Room 1116ESofya Raskhodnikova is an associate professor of Computer Science and Engineering at Penn State.
Raskhodnikova, Sofya
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

05201 Abstracts Collection – Design and Analysis of Randomized and Approximation Algorithms [PDF]

, 2005
From 15.05.05 to 20.05.05, the Dagstuhl Seminar 05201 ``Design and Analysis of Randomized and Approximation Algorithms'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Dyer, Martin, Jerrum, Mark, Karpinski, Marek   +2 more
core   +1 more source

Evaluation of Spatial Clustering Algorithms for Analysis and Division of Hydrogen Ecosystems

, 2023
Geospatial data is of high relevance in modeling of hydrogen ecosystems, for instance to evaluate available areas, transport distances or existing infrastructure.
Weise, Friedrich
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source