Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Reconstructing the professional role of pharmacists in China from the perspective of public value theory: challenges and institutional pathways. [PDF]
Han K +5 more
europepmc +1 more source
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss +9 more
wiley +1 more source
Narratives of nursing students and educators on clinical environment and culture in the context of community of practice: a narrative study. [PDF]
Saraçoğlu M, Gülpinar MA.
europepmc +1 more source
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang +11 more
wiley +1 more source
Interprofessional recognition of audiology scope of practice in hearing and balance care: Evidence from the University of Sharjah. [PDF]
Ayas M, Ravi R, Gunjawate DR.
europepmc +1 more source
An Implanted Tooth That Can Feel
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao +13 more
wiley +1 more source
Positive Insights on Student Research Engagement in Academic Undergraduate General Practice: A Mixed Methods Study. [PDF]
Ravichandran N +5 more
europepmc +1 more source
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
The personal and professional characteristics of students who were successful in occupational therapy practice education: A scoping review. [PDF]
Gebhardt A, Bye RA, Coxon K.
europepmc +1 more source

