Results 91 to 100 of about 4,772,800 (256)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

MEAN-VARIANCE ANALYSIS OF ALTERNATIVE HEDGING STRATEGIES [PDF]

open access: yes
Demand and Price Analysis,
Hague, Terry   +2 more
core   +1 more source

The medium isn’t the message: Introducing a measure of adaptive virtual communication

open access: yesCogent Arts & Humanities, 2018
Media use can be considered as an integral part of virtual communication and thus of present-day human interaction. Nevertheless, research on media use and effects still largely relies on laboratory experiments, treating it as a stable input condition ...
Lisa Handke   +3 more
doaj   +1 more source

Analysis of Molecular Variance (AMOVA) for Autopolyploids

open access: yesFrontiers in Ecology and Evolution, 2018
Autopolyploids present several challenges to researchers studying population genetics, since almost all population genetics theory, and the expectations derived from this theory, has been developed for haploids and diploids.
Patrick G. Meirmans, Shenglin Liu
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Welding Connection Strenght of Aluminium 1100 with Current Variations at Metal Inert Gas (MIG) Welding Process

open access: yesJurnal Energi Dan Manufaktur, 2012
In order to design of machine or building constructions use of welding connection, there are many factors should beconsidered such as skill, knowledge about welding procedures and material characteristics.
I Dewa Made Krishna Muku
doaj  

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