Results 91 to 100 of about 836,736 (281)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Partitioning sums of Squares and Analysis of Variance (ANOVA) in Mixed Linear Model [PDF]

The Egyptian Statistical Journal, 1991
El-Houssainy Rady
doaj   +1 more source

Grain yield performance, correlation, and cluster analysis in elite bread wheat (Triticum aestivum L.) lines

Acta Agrobotanica, 2018
Wheat is a leading cereal, playing a crucial role in feeding the hungry world and improving global food security. The present study was undertaken to comparatively analyze the extent of genetic diversity for various quantitative traits among the wheat ...
Saima Mir Arain, Mahboob Ali Sial, Karim Dino Jamali, Khalil Ahmed Laghari   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Versatility of the Taguchi Method: Optimizing Experiments Across Diverse Disciplines

Journal of Statistical Theory and Applications (JSTA)
The Taguchi method, a robust experimental design technique, establishes a strong connection between input and output variables. Known for its capacity to yield precise results with fewer trials and minimized errors, this method has gained widespread ...
Mohammed Wamique Hisam, Amir Ahmad Dar, Mohammed Osman Elrasheed, Mohammad Shahfaraz Khan, Rajat Gera, Imran Azad   +5 more
doaj   +1 more source

QUANTITATIVE DIFFERENCES WITHIN ANTHROPOMETRIC SPACE WITH FEMALE STUDENTS AT HIGH SCHOOL [PDF]

Sport Mont, 2011
The aim of this research is to determine the differences within anthropometric space with female students attending the regular class activity in physical education at school, the activities being held in different working conditions.
Viktor Mitrevski, Georgi Georgiev, Naser Rashiti, Fadil Nika   +3 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Parameter Sensitivity Analysis for Machining Operation of Autofrettaged Cylinder Using Taguchi Method

Applied Sciences
This study investigates the impact of material parameters such as yield strength (Sy), Young’s modulus (E), and tangent modulus (T) on the safety factor (SF) of autofrettaged cylinders under 400 MPa working pressure, considering the three scenarios: no ...
Murat Oymak, Halil Yıldırım, Mustafa Yıldız, Burak Özcan, Yasin Çelebi, Muhammet Abdullah Enes Çelebi, Veli Çelik   +6 more
doaj   +1 more source

Multivariate analysis and clustering reveal high morphological diversity in Tunisian autochthonous grapes (Vitis vinifera): insights into characterization, conservation and commercialization

OENO One, 2014
Aim: To characterize autochthonous grapevine cultivars from a national germplasm collection, to estimate the phenotypic diversity among and within the cultivars, and to identify the traits that contributed to cultivar heterogeneity.
Myriam Lamine, Hassène Zemni, Sana Ziadi, Asma Chabaane, Imen Melki, Samiha Mejri, Nejia Zoghlami   +6 more
doaj   +1 more source

Resolution of Students t-tests, ANOVA and analysis of variance components from intermediary data

, 2017
Significance testing in comparisons is based on Student’s t-tests for pairs and analysis of variance (ANOVA) for simultaneous comparison of several procedures.
Anders Kallner, Kallner Anders, Kallner, Anders   +2 more
core   +1 more source