Results 81 to 90 of about 174,852,288 (260)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Two-way analysis of variance (ANOVA) for different parameters.
, 2016 Two-way analysis of variance (ANOVA) for different parameters.
Krishnan Muthukumar (3394340) +4 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Analysis of variance (ANOVA) for response surface quadratic model.
, 2016 Analysis of variance (ANOVA) for response surface quadratic model.
Ping Zheng (21877) +6 more
core +1 more source
Antioxidants, 2019 Resveratrol is an antioxidant abundant in red fruits, and one of the most powerful inhibiting reactive oxygen species (ROS) and oxidative stress (OS) produced by human metabolism.
César Leyva-Porras +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Analysis of variance (ANOVA) for reduced response surface quadratic model.
, 2016 Analysis of variance (ANOVA) for reduced response surface quadratic model.
Ping Zheng (21877) +6 more
core +1 more source
, 2021 Physiological reactivity to film clips—Means (M), Standard Deviations (SD), results of Analysis of Variance (ANOVA).
Lukasz D. Kaczmarek (11302134) +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
ANOVA for response surface quadratic model analysis of variance table.
, 2018 ANOVA for response surface quadratic model analysis of variance table.
Zunlai Sheng (5628983) +3 more
core +1 more source