Results 81 to 90 of about 836,736 (281)

Design of U-Geometry Parameters Using Statistical Analysis Techniques in the U-Bending Process

Metals, 2017
The various U-geometry parameters in the U-bending process result in processing difficulties in the control of the spring-back characteristic. In this study, the effects of U-geometry parameters, including channel width, bend angle, material thickness ...
Wiriyakorn Phanitwong, Untika Boochakul, Sutasn Thipprakmas   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of variance (ANOVA) for reduced response surface quadratic model.

, 2016
Analysis of variance (ANOVA) for reduced response surface quadratic model.
Ping Zheng (21877), Jibin Sun (47351), Haixing Li (713285), Dawei Zhang (58801), Huan Fang (747772), Huina Dong (713466), Tao Cai (19539)   +6 more
core   +1 more source

Model comparison in ANOVA [PDF]

, 2016
Analysis of variance (ANOVA), the workhorse analysis of experimental designs, consists of F-tests of main effects and interactions. Yet, testing, including traditional ANOVA, has been recently critiqued on a number of theoretical and practical grounds ...
Morey, Richard D., Morey, Richard, Rouder, Jeffrey N., Rouder, Jeffrey, Engelhardt, Christopher, McCabe, Simon, Engelhardt, Christopher R.   +6 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Use of statistical tools in a development context analysis of variance (ANOVA) [PDF]

, 2015
Material complementari del cas estudi "Use of statistical tools in a development context analysis of variance (ANOVA)", part component del llibre "Case studies for developing globally responsible engineers"Postprint (author's final ...
Ortego Martínez, María Isabel, Lloret, Enric   +1 more
core   +1 more source

ANOVA for response surface quadratic model analysis of variance table.

, 2018
ANOVA for response surface quadratic model analysis of variance table.
Zunlai Sheng (5628983), Ishfaq Muhammad (5628989), Jiahong Zhao (5628986), Ying Zhang (40767)   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Regular and Modified Kernel-Based Estimators of Integrated Variance: The Case with Independent Noise [PDF]

We consider kernel-based estimators of integrated variances in the presence of independent market microstructure effects. We derive the bias and variance properties for all regular kernel-based estimators and derive a lower bound for their asymptotic ...
Neil Shephard, Ole E. Barndorff-Nielsen, Asger Lunde, Peter Reinhard Hansen   +3 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source