Results 61 to 70 of about 785,321 (238)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Partitioning sums of Squares and Analysis of Variance (ANOVA) in Mixed Linear Model [PDF]
The Egyptian Statistical Journal, 1991 El-Houssainy Rady
doaj +1 more source
Acta Agrobotanica, 2018 Wheat is a leading cereal, playing a crucial role in feeding the hungry world and improving global food security. The present study was undertaken to comparatively analyze the extent of genetic diversity for various quantitative traits among the wheat ...
Saima Mir Arain +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The Versatility of the Taguchi Method: Optimizing Experiments Across Diverse Disciplines
Journal of Statistical Theory and Applications (JSTA)The Taguchi method, a robust experimental design technique, establishes a strong connection between input and output variables. Known for its capacity to yield precise results with fewer trials and minimized errors, this method has gained widespread ...
Mohammed Wamique Hisam +5 more
doaj +1 more source
QUANTITATIVE DIFFERENCES WITHIN ANTHROPOMETRIC SPACE WITH FEMALE STUDENTS AT HIGH SCHOOL [PDF]
Sport Mont, 2011 The aim of this research is to determine the differences within anthropometric space with female students attending the regular class activity in physical education at school, the activities being held in different working conditions.
Viktor Mitrevski +3 more
doaj
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Applied SciencesThis study investigates the impact of material parameters such as yield strength (Sy), Young’s modulus (E), and tangent modulus (T) on the safety factor (SF) of autofrettaged cylinders under 400 MPa working pressure, considering the three scenarios: no ...
Murat Oymak +6 more
doaj +1 more source