Results 11 to 20 of about 782,187 (190)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Continuity of LF-algebra representations associated to representations of Lie groups
, 2012 Let G be a Lie group and E be a locally convex topological G-module. If E is sequentially complete, then E and its space of smooth vectors are modules for the algebra D(G) of compactly supported smooth functions on G. However, the module multiplication
Glockner, Helge
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Журнал Белорусского государственного университета: Математика, информатика, 2019 One of the central tasks of financial analysis is the study of the behavior of the dynamics of interest rates. The most wellknown affine models are not able to describe real yield curves with the necessary accuracy, so more and more often researchers ...
Dzmitry A. Pauliu
doaj
Nonlinearity, Proper Actions and Equivariant Stable Cohomotopy
, 2013 In this article we extend the classical definitions of equivariant cohomotopy theory to the setting of proper actions of Lie groups. We combine methods originally developed in the analysis of nonlinear differential equations, mainly in connection with ...
Barcenas, Noe
core +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Minimal representations and reductive dual pairs in conformal field theory
, 2010 A minimal representation of a simple non-compact Lie group is obtained by ``quantizing'' the minimal nilpotent coadjoint orbit of its Lie algebra.
Todorov, Ivan
core +1 more source