Results 21 to 30 of about 782,187 (190)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Monogenic Functions and Representations of Nilpotent Lie Groups in Quantum Mechanics
, 1998 We describe several different representations of nilpotent step two Lie groups in spaces of monogenic Clifford valued functions. We are inspired by the classic representation of the Heisenberg group in the Segal-Bargmann space of holomorphic functions ...
Cnops, Jan, Kisil, Vladimir
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Hopf fibrations are characterized by being fiberwise homogeneous [PDF]
, 2014 Heinz Hopf's famous fibrations of the 2n+1-sphere by great circles, the 4n+3-sphere by great 3-spheres, and the 15-sphere by great 7-spheres have a number of interesting properties.
Haggai Megged Nuchi +2 more
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Geometry and topology of complex hyperbolic and CR-manifolds
, 1997 We study geometry, topology and deformation spaces of noncompact complex hyperbolic manifolds (geometrically finite, with variable negative curvature), whose properties make them surprisingly different from real hyperbolic manifolds with constant ...
Apanasov, Boris
core +2 more sources
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Nilpotence and descent in equivariant stable homotopy theory
, 2016 Let $G$ be a finite group and let $\mathscr{F}$ be a family of subgroups of $G$. We introduce a class of $G$-equivariant spectra that we call $\mathscr{F}$-nilpotent.
Mathew, Akhil +2 more
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source