Results 131 to 140 of about 2,072 (306)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Analytic solutions of n-th order differential equations at a singular point
Electronic Journal of Differential Equations, 2002 Necessary and sufficient conditions are be given for the existence of analytic solutions of the nonhomogeneous n-th order differential equation at a singular point. Let $L$ be a linear differential operator with coefficients analytic at zero.
Brian Haile
doaj
New Inequalities for the Čebyšev Functional Involving Two n-Tuples of Real Numbers and Applications [PDF]
, 2002 New upper and lower bounds for the unweighted Čebyšev functional involving two n−tuples of real numbers are developed and applications for guessing mappings are ...
Cerone, Pietro, Dragomir, Sever S
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
MathematicsThis article proposes a new type of analytic function called Mtan and introduces a new geometric structure that blends exponential and trigonometric properties.
Mohammad El-Ityan +4 more
doaj +1 more source
"On Pricing Barrier Options with Discrete Monitoring" [PDF]
This paper proposes a new approximation method for pricing barrier options with discrete monitoring under stochastic volatility environment. In particular, the integration-by-parts formula and the duality formula in Malliavin calculus are effectively ...
Kenichiro Shiraya +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Analytic Pricing of Contingent Claims Under the Real-World Measure [PDF]
This article derives a series of analytic formulae for various contingent claims under the real-world probability measure using the stylised minimal market model (SMMM).
Eckhard Platen, Shane Miller
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source