Results 41 to 50 of about 1,057,200 (395)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Automated Hybrid Methodology for Software Architecture Style Selection Using Analytic Hierarchy Process and Fuzzy Analytic Hierarchy Process

IET Software
In software engineering, selecting the appropriate architectural style for software systems is risky and sensitive. The selection process is a multicriteria decision-making (MCDM) problem.
Muna Alrazgan, Ahmed Ghoneim, Luluah Albesher, Razan Aldossari, Shahad Alotaibi, Lama Alsaykhan, Norah Alshahrani, Maha Alshammari   +7 more
doaj   +1 more source

An Analytic Hierarchy Process for Selecting Battery Equalization Methods

Energies, 2022
Batteries have been the predominant energy storage system used in electric vehicles. Battery packs have a large number of cells that develop charge, thermal, and capacity imbalances over time, limiting the power, range, and lifetime.
Bruno Martin de Alcântara Dias, Cynthia Thamires da Silva, Rui Esteves Araújo, Ricardo de Castro, Eduardo Lorenzetti Pellini, Cláudio Pinto, Armando Antônio Maria Laganá   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A Survey-Weighted Analytic Hierarchy Process to Quantify Authorship

Advances in Medical Education and Practice, 2021
Edsel B Ing University of Toronto, Toronto, ON, CanadaCorrespondence: Edsel B IngMichael Garron Hospital, 650 Sammon Ave, K306, Toronto, ON, M4C 5M5, CanadaTel +1 416 465-7900Fax +1 416 385-3880Email edingLidStrab@gmail.comBackground: Authorship is a ...
Ing EB
doaj  

Analytic Hierarchy Process, Tourism Attractions, Rural Tourism, East Azarbaijan [PDF]

Rāhburdhā-yi tusi̒ah-i rūstāyī, 2016
Rural non-farm economy is seriously considered for using the full capacity of rural economy in developing countries. Rural tourism is a part of the tourism industry; it can play an important role in rural development, diversification of the national ...
fatemeh kazemiyeh, hasan sadighi, Mohammad Chizari   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

BUILD A MULTI-CRITERIA EVALUATION MODEL FOR THE SELECTION OF A CONTRACTOR IN CONSTRUCTION PROJECTS

Diyala Journal of Engineering Sciences, 2015
The current study provides a methodological framework to regulate the perceptions of decision-makers to take various criteria including increases Foundation benefit and provide them tool supportive of the resolution represented technology FAHP)) to ...
Hafiz Ibrahem Naji
doaj  

Green Degree Comprehensive Evaluation of Elevator Based on Fuzzy Analytic Hierarchy Process

MATEC Web of Conferences, 2015
The green design of the elevator has many characteristics which contains many factors and the combination of qualitative and quantitative. In view of the fuzzy problem of evaluation index information, fuzzy analytic hierarchy process and fuzzy ...
Lizhen, Zhangruijun, WangChen
doaj   +1 more source