Results 51 to 60 of about 51,065 (310)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

METHOD OF REGIONAL INNOVATIVE CLIMATE ASSESSMENT

open access: yesДискурс, 2016
The main elements of innovative development provision at the regional level are presented; methods of bringing to compromise interests of innovative activity participants are studied.
M. A. Kosuhina
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Accommodating Analytic Hierarchy Process (AHP) for Elective Courses Selection

open access: yesIJIE (Indonesian Journal of Informatics Education), 2019
The determination of elective courses for students is one of many things that require some complex considerations. This complexity is motivated by psychological and non-psychological factors of human beings such as: learning motivation, lecturer and ...
Khresna Bayu Sangka, Binti Muchsini
doaj   +1 more source

Extended Fuzzy Analytic Hierarchy Process (E-FAHP): A General Approach

open access: yesMathematics, 2020
Fuzzy analytic hierarchy process (FAHP) methodologies have witnessed a growing development from the late 1980s until now, and countless FAHP based applications have been published in many fields including economics, finance, environment or engineering ...
Javier Reig-Mullor   +2 more
doaj   +1 more source

A Clarification of “Remarks on the Analytic Hierarchy Process” [PDF]

open access: yesManagement Science, 1990
The replies by Saaty (1990) and by Harker and Vargas (1990) to my remarks on the Analytic Hierarchy Process (Dyer 1990) are useful in focusing attention on areas of disagreement regarding the AHP, and provide readers with sufficient information to form their own opinions.
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

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