Results 121 to 130 of about 1,113,738 (296)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analytic mechanics /

, 1943
'A revision of Mechanics of engineering'Includes ...
Chambers, Sherman Daniel,1881-1979, Faires, Virgil Moring   +1 more
core  

PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS

, 2011
The Micro- and Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives, trends, and directions in mechanics of heterogeneous materials in January 2010.
Huang MJ, Shi HJ, Zhao YP, Feng XQ, Wang JX, Peng XH, Cui JZ, 季葆华, Zou WN, Sun QP, Wang YS, He LH, Liu B, Zheng QS, Chen CQ, Hu GK, Duan HL, Zhao HP, Huo YZ   +18 more
core   +1 more source

Digital twin of a large-aspect-ratio Rayleigh–Bénard experiment: role of thermal boundary conditions, measurement errors and uncertainties

Flow
Albeit laboratory experiments and numerical simulations have proven themselves successful in enhancing our understanding of long-living large-scale flow structures in horizontally extended Rayleigh–Bénard convection, some discrepancies with respect to ...
Philipp P. Vieweg, Theo Käufer, Christian Cierpka, Jörg Schumacher   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

1. Baltic - Scandinavian symposium on mechanics Abstracts

, 1990
Available from Latvian Academic Library / LAL - Latvian Academic LibrarySIGLELatvian Academy of Sciences, Riga (Latvia). Inst. of Polymer Mechanics; Riga Technical Univ., Riga (Latvia); Univ. of Latvia, Riga (Latvia).
Latvian Academy of Sciences, Riga (Latvia), Swedish Committee for Theoretical and Applied Mechanics, Stockholm (Sweden)   +1 more
core  

A review on vortex dynamics in the healthy and dilated left ventricles and its application to heart health

Flow
Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications and in some cases death of an individual.
Mahesh S. Nagargoje, Eneko Lazpita, Jesús Garicano-Mena, Soledad Le Clainche   +3 more
doaj   +1 more source

Analytic Geometry and Singularities of Mechanisms

ZAMM, 1998
Summary: We analyze the geometrical structure of the set \(M\) of configurations of a mechanism. Using Lie groups language and without any hypothesis of regularity, one can attach to this set a structure of an analytic variety. We then compute the tangent cone at each point of this set without introducing any coordinates, and we describe the structure ...
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source