Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Construction of an Interpretive Structural Model-Analytic Network Process model for preschool children's drowning risk factors based on the Haddon matrix. [PDF]
Front Public HealthMa F, Luo D, Liu H, Zhao G.
europepmc +1 more source
Theory of the analytic hierarchy and analytic network processes – examples. Part 2.2
Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2013 ?? ?????? ?????????????? ?????????????? ???????? ??????????????????, ??????????????????????, ?????????????????? ???? ?????????????? (BOCR) ?? ???????????????????? ????????????. ????????????????, ???? ?????????????????? ?????? ?????? ????????????????????. ???????????????????? ?????????????? ???? ???????????????? ???????????????? ?????? ???? ???? ????????
openaire +3 more sources
Decision Making with the Analytic Network Process
, 2017 One of the most advanced and complex multi- criteria decision-making methods is the analytic network process (ANP). This method supports modelling dependencies and feedback between elements in the network. For this reason, the ANP is one of the most appropriate methods for making decisions in fields that are characterised by existing dependencies of ...
Divjak, Blaženka +2 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Surgical Intensity and Specialization Preferences in Healthcare: An Operation- and Process-Management Perspective Using Bibliometric Analysis, Cognitive Mapping and Analytic Network Process (ANP). [PDF]
Healthcare (Basel)Kılıç Y +4 more
europepmc +1 more source
An Evaluation of Environmental Governance in Urban China Based on a Hesitant Fuzzy Linguistic Analytic Network Process. [PDF]
Int J Environ Res Public Health, 2018 Gao X, Shi C, Zhai K.
europepmc +1 more source