Results 91 to 100 of about 3,926 (245)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dirichlet series as interfering probability amplitudes for quantum measurements

New Journal of Physics, 2015
We show that all Dirichlet series, linear combinations of them and their analytical continuations represent probability amplitudes for measurements on time-dependent quantum systems.
C Feiler, W P Schleich
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

New approach to the fractional derivatives

International Journal of Mathematics and Mathematical Sciences, 2003
We introduce a new approach to the fractional derivatives of the analytical functions using the Taylor series of the functions. In order to calculate the fractional derivatives of f, it is not sufficient to know the Taylor expansion of f, but we should ...
Kostadin Trenčevski
doaj   +1 more source

The analytic continuation of the discrete series. II [PDF]

Transactions of the American Mathematical Society, 1979
This is the second in a series of papers on the analytic continuation of the holomorphic discrete series. In this paper necessary and sufficient conditions for unitarizability are given in the case of line bundles. The foundations for the vector valued case are begun.
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Spectral continuation study of the temporally periodic solitons of the damped-driven nonlinear Schrödinger equations

, 2012
Includes abstract.Includes bibliographical references.In this thesis we develop and employ a spectral continuation algorithm, implemented in AUTO, to study the temporally periodic spatially localised soliton solutions of the driven, damped nonlinear ...
Lee-Thorpe, James
core  

Self gravitating spinning string condensates

Journal of High Energy Physics
In the context of the black hole/string transition, it is useful to produce Euclidean string backgrounds representing hot and self-gravitating strings.
Jorge E. Santos, Yoav Zigdon
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Direct Kinematics Solution of 3-RCC Parallel Robot using a Semi-Analytical Homotopy Method [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2019
Parallel robots are closed-loop mechanisms presenting very good performances in terms of accuracy, rigidity, and the ability to manipulate large loads. Inverse kinematics problem for most parallel robots is straightforward, while the direct kinematics is
Seyyed Mojtaba Varedi-Koulaei, Masoumeh Rahimi   +1 more
doaj