Results 121 to 130 of about 2,970,127 (311)

Direct Kinematics Solution of 3-RCC Parallel Robot using a Semi-Analytical Homotopy Method [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2019
Parallel robots are closed-loop mechanisms presenting very good performances in terms of accuracy, rigidity, and the ability to manipulate large loads. Inverse kinematics problem for most parallel robots is straightforward, while the direct kinematics is
Seyyed Mojtaba Varedi-Koulaei, Masoumeh Rahimi   +1 more
doaj  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

THE CAUCHY PROBLEM FOR THE SYSTEM OF EQUATIONS OF THERMOELASTICITY IN E^n

International Islamic University Malaysia Engineering Journal, 2014
: In this paper we consider the problem of analytical continuation of solutions to the system of equations of thermoelasticity in a bounded domain from their values and values of their strains on a part of the boundary of this domain, i.e., we study the ...
Ikbol E. Niyozov, O. I. Makhmudov
doaj   +1 more source

Compact Three Dimensional Black Hole: Topology Change and Closed Timelike Curve (minor changes)

, 1993
We present a compactified version of the 3-dimensional black hole recently found by considering extra identifications and determine the analytical continuation of the solution beyond its coordinate singularity by extending the identifications to the ...
Bañados M, Deser S, Fujiwara Y, Gannon D, Geroch R P, Gibbons G W, Hawking S W, Hosoya A, Hosoya A, Masaru Siino, Misner C W, Siino M, Tipler F J, Yodzis P   +13 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

INJURY-RELATED FACTORS ASSOCIATED WITH THE CONTINUATION OF ASSAULT CASES TO COURT BASED ON VISUM ET REPERTUM FINDINGS

Jurnal Kedokteran Diponegoro
Background: A significant number of physical assault cases in Indonesia do not proceed to court, despite victims undergoing forensic medical examinations. The Visum et Repertum (VeR), a legal medical report describing a victim’s injuries, plays a crucial
I Made Raditya Mahardika, Intarniati Nur Rohmah, RP Uva Utomo, Gatot Suharto, Wian Pisia Anggreliana   +4 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source