Results 241 to 250 of about 4,734,550 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Tracing governance transitions: A qualitative framework for analysing shifts from rights-based to entrepreneurial governance regimes. [PDF]

MethodsX
Sahide MAK, Daben MC, Sirimorok N, Santika T.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Quality and Authenticity Evaluation of Red Yeast Rice Food Supplements from the Bulgarian Market. [PDF]

Foods
Todorova V, Dzhakova Z, Ivanov K, Grekova-Kafalova D, Slavcheva K, Ivanova S.   +5 more
europepmc   +1 more source

Film as Ethical Experience in Engineering Education: Three Modes of Ethical Engagement. [PDF]

Sci Eng Ethics
Käkelä N, Lennerfors TT, Hitt S.
europepmc   +1 more source

Illuminating the black box: Mapping the fates of polymeric micelle drug carriers <i>in vivo</i>. [PDF]

Acta Pharm Sin B
Ding X.
europepmc   +1 more source

A New Lens on Glycolipid Isomers in Spatial Neurobiology. [PDF]

ACS Cent Sci
Angel PM.
europepmc   +1 more source

An environmental type-recessiveness framework for the spatial coupling of environmental heterogeneity and ICH recessiveness in Guizhou's ethnic minority villages, China. [PDF]

PLoS One
Guo R, Yao A.
europepmc   +1 more source