Results 91 to 100 of about 2,375,122 (290)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The Analyst : The Journal of the Society for Analytical Chemistry
, 1972 1008 hal,;ill,;27 ...
Society for Analytical Chemistry
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Acceleration Energies and Higher-Order Dynamic Equations in Analytical Mechanics
MathematicsThe dynamic study of current and rapid movements of rigid and multibody mechanical systems, according to differential principles from dynamics, is based on advanced concepts from analytical mechanics: kinetic energy, higher-order acceleration energies ...
Iuliu Negrean +2 more
doaj +1 more source
Mechanisms of Lagrangian Analyticity in Fluids [PDF]
Archive for Rational Mechanics and Analysis, 2019 Certain systems of inviscid fluid dynamics have the property that for solutions that are only slightly better than differentiable in Eulerian variables, the corresponding Lagrangian trajectories are analytic in time. We elucidate the mechanisms in fluid dynamics systems that give rise to this automatic Lagrangian analyticity, as well as mechanisms in ...
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS
, 2011 The Micro- and Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives, trends, and directions in mechanics of heterogeneous materials in January 2010.
Huang MJ +18 more
core +2 more sources
Modeling and Analysis of Aeroelasticity and Sloshing for Liquid Rocket
IEEE Access, 2019 In this paper, based on the advantages of Newtonian mechanics method, mixed coordinate method, and analytical mechanics method, the dynamic model of rigid-aeroelasticity-sloshing coupling is established for longitudinal vibration and liquid fuel sloshing,
Dewei Zhang +4 more
doaj +1 more source
Mesofracture mechanics: a necessary link
, 2001 Classical fracture mechanics is based on the premise that small scale features could be averaged to give a larger scale property such that the assumption of material homogeneity would hold.
Sih, GC (reprint author), Xian Jiaotong Univ, Sch Adv Sci & Technol, Xian 710049, Shaanxi, Peoples R China. +2 more
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