Results 111 to 120 of about 2,375,122 (290)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Analytical and Applied Mechanics
The Mathematical Gazette, 1937 J. W. Campbell +2 more
openaire +2 more sources
Proceedings of the fifth Canadian Soil Mechanics Conference, January 10 and 11, 1952
, 1952 This is the record of a Conference of most of the active Canadian workers in the field of soil mechanics, held in the Seminar Room of the Montreal Road Laboratories of the National Research Councilor Canada, in Ottawa on January 10-11, 1952, under the ...
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Fundamentals and Applications of Fluid Mechanics and Acoustics in Biomedical Engineering
BioengineeringThe field of biomedical engineering has experienced important recent advances in experimental, computational, and analytical research in fluid mechanics and acoustics [...]
Iris Little, Ephraim Gutmark
doaj +1 more source
Investigating the suitability of Analytical and Semi-analytical Satellite theories for Space Object Catalogue maintenance in Geosynchronous regime [PDF]
, 2013 Currently, the number of space debris particles is about 33,500, out of which approximately 1100 are in geosynchronous orbits, which are tracked and whose orbital data are provided from US Space surveillance network, with instances of colliding and ...
Setty, Srinivas +3 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analytic Geometry and Singularities of Mechanisms
ZAMM, 1998 Summary: We analyze the geometrical structure of the set \(M\) of configurations of a mechanism. Using Lie groups language and without any hypothesis of regularity, one can attach to this set a structure of an analytic variety. We then compute the tangent cone at each point of this set without introducing any coordinates, and we describe the structure ...
openaire +3 more sources