Results 111 to 120 of about 3,397,715 (333)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Integrated analysis and design of thick composite structures for optimal passive damping characteristics [PDF]
The development of novel composite mechanics for the analysis of damping in composite laminates and structures and the more significant results of this effort are summarized.
Saravanos, D. A.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Advances in Civil Engineering, 2008 Analytical vulnerability assessment methods should ideally be validated or verified by comparing their damage predictions with actual observed damage data.
H. Crowley +4 more
doaj +1 more source
Asymptotic analytical methods in fluid mechanics related to drag prediction [PDF]
Some recent theoretical work of a purely analytical nature is described which promises to provide engineering predictions for the important drag-related phenomena of flow in the stall regime. This analytical work deals with rigorous asymptotic studies of
Inger, G. R.
core +1 more source
Analytical continuum mechanics à la Hamilton-Piola: least action principle for second gradient continua and capillary fluids [PDF]
, 2013 Nicolas Auffray +4 more
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Cross-Coupled Heat and Moisture Transport Part 2/1: Applications in Mechanics
Journal of Mechanical Engineering, 2018 Based on the theory laid down in the Part 1 [1] in this paper we are going to display applications in physics and especially in mechanics. After a short summary on coupled fields in mechanics, we generally analyze the analogies in mechanics.
Andras Szekeres, Balazs Fekete
doaj +1 more source