Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
CALIPSO 1064 nm calibration biases inferred from wavelength-dependent signal attenuation by stratospheric aerosols [PDF]
Atmospheric Measurement TechniquesCalibration of lidar signals at 1064 nm from the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) onboard Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite depends on the prior calibration of the primary 532 ...
J. Kar +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A simple proof of Born’s rule for statistical interpretation of quantum mechanics [PDF]
, 2017 The Born’s rule to interpret the square of wave function as the probability to get a specific value in measurement has been accepted as a postulate in foundations of quantum mechanics.
Dikshit, Biswaranjan
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Analytical continuum mechanics à la Hamilton-Piola: least action principle for second gradient continua and capillary fluids [PDF]
, 2013 Nicolas Auffray +4 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An analytical method for calculation of integrals appearing in approximate solutions of deformable body mechanics [PDF]
, 1988 T. Wegner
openalex +1 more source
Asymptotic analytical methods in fluid mechanics related to drag prediction [PDF]
Some recent theoretical work of a purely analytical nature is described which promises to provide engineering predictions for the important drag-related phenomena of flow in the stall regime. This analytical work deals with rigorous asymptotic studies of
Inger, G. R.
core +1 more source