Results 21 to 30 of about 3,823,122 (261)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A Generalized Analytical Mechanics in which Quantum Phenomena Appear [PDF]
, 2015 We propose a mechanics of a massive particle in a potential field effective for both classical and quantum system as a modified classical analytical mechanics (modified CM). We transform, under coordinate transformation, the covariant tensor of order two
Yasuda, Masao
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Changes of the topological charge of vortices
, 2002 We consider changes of the topological charge of vortices in quantum mechanics by investigating analytical examples where the creation or annihilation of vortices occurs.
Andronikashvili E L +17 more
core +1 more source
On the Analytical Mechanics of Chemical Reactions. Classical Mechanics of Linear Collisions [PDF]
, 1966 The classical mechanics of chemically reactive linear collisions is investigated for vibrationally near‐adiabatic reactions. A coordinate system which passes smoothly from one suited to the reactants to one suited to the products is used.
Marcus, R. A.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A variational formulation of analytical mechanics in an affine space
, 2006 Variational formulations of statics and dynamics of mechanical systems controlled by external forces are presented as examples of variational principles.Comment: 17 pages, corrected typos, accepted for publication in Rep.
Antonio De Nicola +4 more
core +1 more source
The ZX-calculus is incomplete for quantum mechanics [PDF]
, 2014 We prove that the ZX-calculus is incomplete for quantum mechanics. We suggest the addition of a new 'color-swap' rule, of which currently no analytical formulation is known and which we suspect may be necessary, but not sufficient to make the ZX-calculus
de Witt, Christian Schröder +1 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source