Results 61 to 70 of about 3,397,715 (333)

Variational aspects of analytical mechanics

, 2011
In this paper we set out to revisit some basic variational aspects of Analytical Mechanics in one independent variable, in a way that would be most appealing to those who are being introduced to Mechanics while having some background in elementary ...
G. Gorni, G. Zampieri
semanticscholar   +1 more source

Why emerging leaders should focus on being good postdoctoral supervisors

FEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski, Clara Oudenaarden, Miao Tian, Diyavarshini Gopaul, Anita Kurilla, Pelin Gülizar Ersan   +5 more
wiley   +1 more source

Entropy regularized reinforcement learning using large deviation theory

Physical Review Research, 2023
Reinforcement learning (RL) is an important field of research in machine learning that is increasingly being applied to complex optimization problems in physics.
Argenis Arriojas, Jacob Adamczyk, Stas Tiomkin, Rahul V. Kulkarni   +3 more
doaj   +1 more source

Validation of a finite element model for fracture mechanics specimens [PDF]

, 2012
Single parameter formulations have shown to be insufficient to describe constraint effects in fracture mechanics specimens. This has lead researchers to a two parameter approach like the J-Q theory. In order to investigate constraint effects, the authors
Cauwelier, Matthias, De Waele, Wim, Hertelé, Stijn, Maelfait, Jens, Van Minnebruggen, Koen, Verstraete, Matthias   +5 more
core  

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

An analytical model for elasto-plastic buckling of columns [PDF]

, 2013
The theory of buckling strength of compression members in the plastic range has been extensively studied, and numerical methods already exist which deal with such behaviour.
Izzuddin, B.A., Jowhari Moghadam, S.
core  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Sea salt reactivity over the northwest Atlantic: an in-depth look using the airborne ACTIVATE dataset [PDF]

Atmospheric Chemistry and Physics
Chloride (Cl−) displacement from sea salt particles is an extensively studied phenomenon with implications for human health, visibility, and the global radiation budget.
E.-L. Edwards, Y. Choi, Y. Choi, E. C. Crosbie, E. C. Crosbie, J. P. DiGangi, G. S. Diskin, C. E. Robinson, C. E. Robinson, M. A. Shook, E. L. Winstead, E. L. Winstead, L. D. Ziemba, A. Sorooshian, A. Sorooshian   +14 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source