Results 61 to 70 of about 34,658 (254)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modeling and Analysis of Aeroelasticity and Sloshing for Liquid Rocket

IEEE Access, 2019
In this paper, based on the advantages of Newtonian mechanics method, mixed coordinate method, and analytical mechanics method, the dynamic model of rigid-aeroelasticity-sloshing coupling is established for longitudinal vibration and liquid fuel sloshing,
Dewei Zhang, Hui Qi, Jiangtao Xu, Ya Yang, Bangsheng Fu   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Acceleration Energies and Higher-Order Dynamic Equations in Analytical Mechanics

Mathematics
The dynamic study of current and rapid movements of rigid and multibody mechanical systems, according to differential principles from dynamics, is based on advanced concepts from analytical mechanics: kinetic energy, higher-order acceleration energies ...
Iuliu Negrean, Adina Veronica Crișan, Sorin Vlase   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Mechanics Property Analysis of High-resistance Steel Wire Mesh in Slope Flexible Stabilization System

Chemical Engineering Transactions, 2015
This paper aims at studying deformation mechanism and mechanics property of high-resistance steel wire mesh in slope flexible stabilization system and makes theoretical analysis under unilateral tension, and the analytical results are compared with the ...
G.S. Wang, S.Q. Shi, M. Wang
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CALIPSO 1064 nm calibration biases inferred from wavelength-dependent signal attenuation by stratospheric aerosols [PDF]

Atmospheric Measurement Techniques
Calibration of lidar signals at 1064 nm from the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) onboard Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite depends on the prior calibration of the primary 532 ...
J. Kar, J. Kar, M. A. Vaughan, R. P. Damadeo, M. Kovilakam, M. Kovilakam, J. L. Tackett, C. R. Trepte   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Theoretical analysis of transverse impact response in double layer graphene sheets

AIP Advances, 2016
In designing future nanoscale devices or nanostructures as new element in structural mechanics, it is very important to predict the responses for these elements against various mechanical loading conditions.
Toshiaki Natsuki, Qing-Qing Ni
doaj   +1 more source