Results 61 to 70 of about 41,264 (251)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Advances in CALIPSO (IIR) cirrus cloud property retrievals – Part 2: Global estimates of the fraction of cirrus clouds affected by homogeneous ice nucleation [PDF]

Atmospheric Chemistry and Physics
Cirrus clouds can form through two ice nucleation pathways (homo- and heterogeneous ice nucleation; henceforth hom and het, respectively) that result in very different cloud physical and radiative properties.
D. L. Mitchell, A. Garnier
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Comparison of Two Mechanics-Based Methods for Simplified Structural Analysis in Vulnerability Assessment

Advances in Civil Engineering, 2008
Analytical vulnerability assessment methods should ideally be validated or verified by comparing their damage predictions with actual observed damage data.
H. Crowley, B. Borzi, R. Pinho, M. Colombi, M. Onida   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Sea salt reactivity over the northwest Atlantic: an in-depth look using the airborne ACTIVATE dataset [PDF]

Atmospheric Chemistry and Physics
Chloride (Cl−) displacement from sea salt particles is an extensively studied phenomenon with implications for human health, visibility, and the global radiation budget.
E.-L. Edwards, Y. Choi, Y. Choi, E. C. Crosbie, E. C. Crosbie, J. P. DiGangi, G. S. Diskin, C. E. Robinson, C. E. Robinson, M. A. Shook, E. L. Winstead, E. L. Winstead, L. D. Ziemba, A. Sorooshian, A. Sorooshian   +14 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Finite element simulation of barge impact into a rigid wall

Alexandria Engineering Journal, 2014
The forces and locations of inland barge impacts currently control the design specifications for lock walls. This has resulted in a significant increase in the final construction costs of these walls.
H.W. Leheta, A.M. Elhewy, W. El Sayed Mohamed   +2 more
doaj   +1 more source