Results 61 to 70 of about 36,819 (252)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling thermo-mechanical fatigue for rolling die under continuous casting process
Results in EngineeringIn the continuous casting process, the rolling die is exposed to non-steady stress conditions that can initiate thermo-mechanical fatigue damage. Understanding the rolling die failure mechanism is essential in metal-forming industries.
Mesay Alemu Tolcha, Hirpa Gelgele Lemu
doaj +1 more source
"Analytical and numerical study of some problems in nonlinear mechanics" [PDF]
مجلة القراءة والمعرفةThis study deals with the topic of “Analytical and numerical study of some problems in nonlinear mechanics.” The study aimed to analyze a problem in nonlinear mechanics, which is “wave function collapse.” Which is represented by the laboratory experiment
Ibtihal Mohammed ALSalem
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Conditions of equivalence of effects for the solid body from incompressible material
MATEC Web of Conferences, 2018 Polemicizing with the existing opinion that modern numerical methods allow to solve practically any problem of mechanics, it should be noted that analytical and experimental methods still are relevant, and a complex of methods leads to development of ...
Agakhanov Elephan +3 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mechanisms of Lagrangian Analyticity in Fluids [PDF]
Archive for Rational Mechanics and Analysis, 2019 Certain systems of inviscid fluid dynamics have the property that for solutions that are only slightly better than differentiable in Eulerian variables, the corresponding Lagrangian trajectories are analytic in time. We elucidate the mechanisms in fluid dynamics systems that give rise to this automatic Lagrangian analyticity, as well as mechanisms in ...
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Acceleration Energies and Higher-Order Dynamic Equations in Analytical Mechanics
MathematicsThe dynamic study of current and rapid movements of rigid and multibody mechanical systems, according to differential principles from dynamics, is based on advanced concepts from analytical mechanics: kinetic energy, higher-order acceleration energies ...
Iuliu Negrean +2 more
doaj +1 more source