Analytical Quality by Design Based Systematic Development and Optimization of a Sensitive Bioanalytical Method for Estimation Cinacalcet HCl in Rabbit Serum. [PDF]
J Pharm Bioallied Sci, 2021 Routray SB, Patra CN, Swain S, Jena BR.
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Coffee by Design Supports the Community
, 2019 Description of Coffee By Design\u27s Rebel Blend Fund Grant. Briefly describes Coffee by Design and the fund, which uses proceeds from the sale of the company\u27s Rebel Blend coffee to grant money to art projects in Maine.
Coffee by Design
core
Eco-friendly estimation of isosorbide dinitrate and hydralazine hydrochloride using Green Analytical Quality by Design-based UPLC Method. [PDF]
RSC Adv, 2021 Chanduluru HK, Sugumaran A.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Discover ChemistryReverse-phase high-performance liquid chromatography (RP-HPLC) has continued to remain one of the most extensively employed analytical techniques in pharmaceutical analysis, with its high robustness, accuracy, and applicability.
Sushma Madhavaram, Judy Jays
doaj +1 more source
Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method. [PDF]
Int J Anal Chem, 2021 Alruwaili NK.
europepmc +1 more source
"Analytical Quality by Design: A Review for Chromatography"
Biomedical Journal of Scientific & Technical Research, 2022 openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
In this study, a quantitative profiling method for detecting free fatty acids in crude lanolin based on the Quality by Design (QbD) concept was developed.
Sihan Liu +3 more
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