Results 1 to 10 of about 3,970,027 (192)

Investigation of aflatoxins occurrence in flavoring preparations for the alcoholic beverage industry

Frontiers in Food Science and Technology, 2023
An exploratory study was carried out to determine the occurrence of aflatoxins B1, B2, G1, and G2 in different aromatic preparations used in the production of bitters, liqueurs and flavored wines.
Bruna Laratta, Serena Carpentieri, Domenico Cautela   +2 more
doaj   +1 more source

Determination of a novel anticonvulsant drug GIZh-290 in rat plasma by liquid chromatography–tandem mass spectrometry

Фармакокинетика и Фармакодинамика, 2022
GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures of racetams that combine anticonvulsant and nootropic effects. The method of high-performance liquid chromatography with mass spectrometric detection was developed and validated
P. O. Bochkov, I. P. Khrustova, A. A. Litvin, G. B. Kolyvanov, R. V. Shevchenko, V. P. Zherdev   +5 more
doaj   +1 more source

Alternative methods in toxicology: pre-validated and validated methods [PDF]

Interdisciplinary Toxicology, 2011
The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds.
Kandárová, Helena, Letašiová, Silvia
openaire   +2 more sources

Quantification of a potential anticonvulsant drug GIZh-298 in rat plasma by liquid chromatography-mass spectrometry

Фармакокинетика и Фармакодинамика, 2022
GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative determination of GIZh-298 in rat blood plasma has been developed and validated.
P. O. Bochkov, O. Yu. Kravtsova, G. B. Kolyvanov, A. A. Litvin, S. S. Boyko, V. P. Zherdev   +5 more
doaj   +1 more source

Validation of a Screening Method Based on a Needle Stochastic Sensor for the Determination of Interleukins 1β, 6, and 12 in Biological Samples

Proceedings, 2020
Interleukins proved to be valuable biomarkers for different diseases. Interleukins 1β, 6, and 12 can be used as biomarkers for brain cancer diagnosis, and therefore this paper proposed a needle stochastic sensor based on protoporphyrin IX immobilized in ...
Sorin Sebastian Gheorghe, Ruxandra Maria Ilie-Mihai, Raluca-Ioana Stefan-van Staden, Alexandru Bratei   +3 more
doaj   +1 more source

On the mathematical validity of the Higuchi method [PDF]

Physica D: Nonlinear Phenomena, 2020
In this paper, we discuss the Higuchi algorithm which serves as a widely used estimator for the box-counting dimension of the graph of a bounded function $f : [0,1] \to \R$. We formulate the method in a mathematically precise way and show that it yields the correct dimension for a class of non-fractal functions.
Liehr, Lukas, Massopust, Peter
openaire   +2 more sources

Comparison of EI-GC-MS/MS, APCI-LC-MS/MS, and ESI-LC-MS/MS for the Simultaneous Analysis of Nine Nitrosamines Eluted from Synthetic Resins into Artificial Saliva and Health Risk Assessment

Toxics, 2021
Nitrosamines can be produced during the manufacture of rubber-type products such as pacifiers or the nipples of baby bottles. Humans can be exposed to the nitrosamines in these products when they are eluted into saliva.
Hyungsoo Kim, Daekwan Sung, Honghyeon Yu, Daeyong Jang, Yeji Koo, Seungha Lee, Kyungmin Lim, Dalwoong Choi   +7 more
doaj   +1 more source

Method Validation and Investigation of the Levels of Pharmaceuticals and Personal Care Products in Sludge of Wastewater Treatment Plants and Soils of Irrigated Golf Course

Molecules, 2020
The validation of a sensitive and reliable analytical procedure for the determination of pharmaceutical and personal care products (PPCPs) in solid environmental samples is reported in this study.
Olufemi Temitope Ademoyegun, Omobola Oluranti Okoh, Anthony Ifeanyi Okoh   +2 more
doaj   +1 more source

Validação de método para determinação de resíduos de amoxicilina aplicado à validação de limpeza em indústria farmacêutica de penicilânicos Validation of a method for determination of amoxicillin residues applied to cleaning validation process in penicillins pharmaceutical industry

Química Nova, 2010
The aim of this work was the single-laboratory validation of a quantitative method for the determination of amoxicillin residues in support of cleaning control and validation.
Maria Luiza Pinheiro Costa Gomes, Scheilla Vitorino Carvalho de Souza   +1 more
doaj   +1 more source

Cross-validation in nonparametric regression with outliers [PDF]

, 2005
A popular data-driven method for choosing the bandwidth in standard kernel regression is cross-validation. Even when there are outliers in the data, robust kernel regression can be used to estimate the unknown regression curve [Robust and Nonlinear Time ...
Leung, Denis Heng-Yan
core   +3 more sources