Results 41 to 50 of about 1,686,969 (265)

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Non-Targeted Nuclear Magnetic Resonance Analysis for Food Authenticity: A Comparative Study on Tomato Samples

Molecules
Non-targeted NMR is widely accepted as a powerful and robust analytical tool for food control. Nevertheless, standardized procedures based on validated methods are still needed when a non-targeted approach is adopted.
Biagia Musio, Rosa Ragone, Stefano Todisco, Antonino Rizzuti, Egidio Iorio, Mattea Chirico, Maria Elena Pisanu, Nadia Meloni, Piero Mastrorilli, Vito Gallo   +9 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Analytical Evaluation of the Autobio 25-OH Vitamin D Assay: Comparison with Liquid Chromatography–Tandem Mass Spectrometry and Clinical Implications

Metabolites
Background: 25-Hydroxy vitamin D [25(OH)D] is the circulating form of vitamin D. Its deficiency is a major global health concern, affecting over one billion people. Beyond its role in bone health, low vitamin D levels have been implicated in a wide range
Flaminia Tomassetti, Eleonora Nicolai, Martina Pelagalli, Federico Cortese, Alfredo Giovannelli, Sabrina Ballerini, Alessia Mozzi, Anastasia De Luca, Massimo Pieri, Sergio Bernardini   +9 more
doaj   +1 more source

Development and Validation of a Simple and Sensitive LC-MS/MS Method for Quantification of Metformin in Dried Blood Spot Its Application as an Indicator for Medication Adherence

International Journal of General Medicine, 2021
Bushra T ALquadeib,1,* Nouf M Aloudah,2,* Alanood S Almurshedi,1 Iman M ALfagih,1 Basmah N ALdosari,1 Adim S ALmeleky,3 Nour M Almubyedh3 1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11671, Saudi Arabia ...
ALquadeib BT, Aloudah NM, Almurshedi AS, ALfagih IM, ALdosari BN, ALmeleky AS, Almubyedh NM   +6 more
doaj  

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

The Absorption, Distribution, Excretion, and In Vitro Hepatic Microsomal Metabolism of the Novel CDK Compound XMD12 in Sprague-Dawley Rats

Pharmaceutics
Background: Cyclin-dependent kinase 4/6 (CDK4/6) represents one of the clinically validated and therapeutically effective anticancer targets. Methods: This study established a rapid and sensitive HPLC-MS/MS method for quantitative determination of XMD12,
Xue-Hai Zheng, Yan-Chun Chang, Yong-Hui Li, Yu-Xia He, Pei-Xiong Zhao, Fei-Fei Wang, Jun-Yu Xu, Yin-Feng Tan   +7 more
doaj   +1 more source

Validated HPLC method for quantification of copanlisib in mice plasma: application to a pharmacokinetic study

ADMET and DMPK, 2020
Copanlisib is a pan phosphatidylinositol 3-kinase (PI3K) inhibitor approved for follicular lymphoma. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of ...
Ashok Zakkula, Pavan Kumar Kurakula, Sreekanth Dittakavi, Prasanthi Daram, Ram Murthi Bestha, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi   +7 more
doaj   +1 more source

Validation of Rapid Microbiological Methods [PDF]

SLAS Technology, 2015
Classical microbiological methods currently have unacceptably long cycle times. Rapid microbiological methods have been available on the market for decades and have been applied by the clinical and food industries. However, their implementation in the pharmaceutical industry has been hampered by stringent regulations on validation and comparison with ...
Vives-Peris, Vicente, Carda-Broch, Samuel, Esteve-Romero, Josep   +2 more
openaire   +3 more sources