Results 51 to 60 of about 1,892,546 (315)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Combining different validation techniques for continuous software improvement - Implications in the development of TRNSYS 16 [PDF]
, 2004 Validation using published, high quality test suites can serve to identify different problems in simulation software: modeling and coding errors, missing features, frequent sources of user confusion.
Bradley, David E. +7 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Applied SciencesConventional methods for testing steroids and hormones (SHs) in environmental samples are exhaustive, complex, and score poorly in sustainability matrices. Therefore, this study evaluates the automated sample preparation approach using the modular Biomek
Bhaskar Karubothula +8 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Robust generalized cross-validation for choosing the regularization parameter [PDF]
, 2006 Let fλ be the regularized solution for the problem of estimating a function or vector f0 from noisy data yi ≤ Lif0 + εi, i ≤ 1, ..., n, where Li are linear functionals.
Lukas, M.A.
core +1 more source
FoodsPhytohormones are key signaling molecules that regulate plant growth, stress adaptation, and fruit ripening. However, their low abundance and structural diversity complicate accurate quantification in food matrices.
Muhammad K. Hakeem +7 more
doaj +1 more source
Validation of Rapid Microbiological Methods [PDF]
SLAS Technology, 2015 Classical microbiological methods currently have unacceptably long cycle times. Rapid microbiological methods have been available on the market for decades and have been applied by the clinical and food industries. However, their implementation in the pharmaceutical industry has been hampered by stringent regulations on validation and comparison with ...
Vives-Peris, Vicente +2 more
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Acute coronary syndrome: validation of the method used to monitor incidence in Australia [PDF]
, 2014 The algorithm currently in use may underestimate the incidence of acute coronary events in Australia, according to this validation study. Overview Monitoring the incidence of acute coronary events is critical to assess the health and economic burden of
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