Results 71 to 80 of about 1,892,546 (315)

Method Validation Data.xlsx [PDF]

, 2020
Data for method validation on detecting pmp-glucose by ...
Norberto Gonzalez (7553942), Alanah Fitch (2239930)   +1 more
core   +1 more source

The Absorption, Distribution, Excretion, and In Vitro Hepatic Microsomal Metabolism of the Novel CDK Compound XMD12 in Sprague-Dawley Rats

Pharmaceutics
Background: Cyclin-dependent kinase 4/6 (CDK4/6) represents one of the clinically validated and therapeutically effective anticancer targets. Methods: This study established a rapid and sensitive HPLC-MS/MS method for quantitative determination of XMD12,
Xue-Hai Zheng, Yan-Chun Chang, Yong-Hui Li, Yu-Xia He, Pei-Xiong Zhao, Fei-Fei Wang, Jun-Yu Xu, Yin-Feng Tan   +7 more
doaj   +1 more source

Validated HPLC method for quantification of copanlisib in mice plasma: application to a pharmacokinetic study

ADMET and DMPK, 2020
Copanlisib is a pan phosphatidylinositol 3-kinase (PI3K) inhibitor approved for follicular lymphoma. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of ...
Ashok Zakkula, Pavan Kumar Kurakula, Sreekanth Dittakavi, Prasanthi Daram, Ram Murthi Bestha, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Bioanalytical method development and validation [PDF]

, 2014
Bioanalytical methods are used for the quantitative analysis of drugs and their metabolites in the biological media like saliva, urine, plasma, serum. Development and validation of bioanalytical method is important to understand the pharmacokinetics of ...
Kumar, Jitendra, Chakole, R. D., Welankiwar, A. S., Charde, Manoj S.   +3 more
core   +2 more sources

Brief Analysis of the Validation of Analytical Methods for Radiopharmaceuticals

Journal of Isotopes
Method validation is an important step to ensure the accuracy and reliability of analytical method，and is the basis for ensuring the controllable quality of drugs.
Mengyi CHEN, Weihua CHENG, Hongyu LI
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Methods and tools for developing an information system for validation of non-formal learning outcomes [PDF]

, 2020
The publication describes methods and tools for development an information system (IS) for acceptance of the non-formal and informal learning results on base of computer ontologies.
Strokan', О.V., Pryima, S.M., Rogushina, J.V., Gladun, A.Y., Mozhovenko, A.A.   +4 more
core  

Quantitative and Comparative Assessment of Recombinant Human β-Glucocerebrosidase Uptake Bioactivity Using a Stable hMMR-Expressing CHO Cell Model

Molecules
Inconsistent conclusions on the cellular uptake of recombinant human β-glucocerebrosidase (rhGCase) for Gaucher disease stem from a fundamental limitation of existing methods: their inability to generate complete and reliable dose–response curves.
Lyuyin Wang, Kaixin Xu, Ping Lyu, Xinyue Hu, Jing Li   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source