Results 11 to 20 of about 1,574,930 (285)

AQbD-driven development of a green RP-HPLC method for nirogacestat with LC–MS structural elucidation [PDF]

BMC Chemistry
Nirogacestat (NGT), a recently approved γ-secretase inhibitor for desmoid tumors, requires sensitive and sustainable analytical methods for impurity profiling.
Jayanthi Sabi, Kanaka Parvathi Kannaiah, Hemanth Kumar Chanduluru, Srinivas Nakka, Samar H. Elagamy, Reem H. Obaydo   +5 more
doaj   +2 more sources

Quality by design approach with design of experiment for sample preparation techniques

Advances in Sample Preparation, 2023
The quality by design (QbD) based approach has begun to be embedded in various method development. Studies show that with the design of experiment tool, the analysis process has become more efficient, faster, and easier.
Saniye Özcan, Serkan Levent, Nafiz Öncü Can   +2 more
doaj   +1 more source

Implementing greening into design in analytical chemistry

Talanta Open, 2022
From the pharmaceutical industry is known the approach Quality-by-Design (QbD) and this has great influence on analytical methods and procedures it employs.
Jelena Jurjeva, Mihkel Koel
doaj   +1 more source

Development of a robust and reliable reverse-phase high-performance liquid chromatography (RP-HPLC) method using analytical quality by design principles for the accurate determination of esculin in its bulk form

Future Journal of Pharmaceutical Sciences, 2023
Background Analytical quality by design is a proactive, holistic, and data-driven approach to quality that emphasizes risk assessment and management. This can lead to more robust and reliable methods than traditional approaches.
Sarvesh Patil, Anjana Adhyapak, Priya Shetti, Rohan Gurao   +3 more
doaj   +1 more source

Ecofriendly analytical quality by design-based method for determining Metronidazole, Lidocaine and Miconazole using RP-HPLC in semisolid dosage form

Journal of Taibah University for Science, 2023
The article deals with the development of an analytical method based on AQbD and GAC for the simultaneous determination of Metronidazole (MET), Lidocaine (LID) and Miconazole (MIC) in oval dosage form using RP-HPLC.
Viswanathan Sukumar, Hemanth Kumar Chanduluru, Saravanan Chinnusamy   +2 more
doaj   +1 more source

Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Future Journal of Pharmaceutical Sciences, 2022
Background The development of chromatographic method and the validation of a sensitive, simple, efficient, and reversed-phase high-performance liquid chromatography (RP-HPLC) approach were adopted for the drug flurbiprofen (FBP) in nanoparticles ...
Shilpa R. Mandpe, Vishal R. Parate, Jitendra B. Naik   +2 more
doaj   +1 more source

Analytical Quality by Design

Brazilian Journal of Analytical Chemistry, 2021
Throughout the 20th century, the notion of ‘quality’ underwent major changes. The concept of ‘Quality by Testing’, i.e. evaluating the quality of a product by testing it for some pre-defined parameters after completing the manufacturing process, started to be replaced by the enhanced approach of Quality by Design (QbD).
openaire   +1 more source

Analytical Quality by Design, Life Cycle Management, and Method Control [PDF]

The AAPS Journal, 2022
AbstractAnalytical methods are utilized throughout the biopharmaceutical and vaccines industries to conduct research and development, and to help control manufacturing inputs and outputs. These analytical methods should continuously provide quality data to support decisions while managing the remaining of risk and uncertainty.
Thorsten Verch, Cristiana Campa, Cyrille C. Chéry, Ruth Frenkel, Timothy Graul, Nomalie Jaya, Bassam Nakhle, Jeremy Springall, Jason Starkey, Jette Wypych, Todd Ranheim   +10 more
openaire   +2 more sources

Environmental benign RP-HPLC method for the simultaneous estimation of anti-hypertensive drugs using analytical quality by design

Green Chemistry Letters and Reviews, 2023
Green analytical procedures replace harmful organic modifiers with green solvents without affecting chromatographic performance, enabling industries and research laboratories to develop green analytical methods.
Naveenarani Dharuman, Karunanidhi Santhana Lakshmi, Manikandan Krishnan   +2 more
doaj   +1 more source

Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments

Future Journal of Pharmaceutical Sciences, 2023
Background A combination of pioglitazone hydrochloride with teneligliptin hydrobromide hydrate is used to treat type-2 diabetes. Several chromatographic techniques have been described in the literature for determination of each of these medications ...
Pintu Prajapati, Bageshree Rana, Veera Shakar Pulusu, Shailesh Shah   +3 more
doaj   +1 more source