Results 201 to 210 of about 352,913 (253)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Emerging quality-by-design optimized HPLC method for the concurrent determination of cefixime and ornidazole: a multi-criteria green and blue environmental footprinting. [PDF]

Sci Rep
Mostafa YE, Elsebaei F, Metwally ME.
europepmc   +1 more source

Analytical Quality by Design in Pharmaceutical Method Validation

Dr Vijayamma G, Dr Sandhiya V, Mahalakshmi R   +2 more
openaire   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Candexch algorithm-enhanced chemometric determination of a novel anti-COVID-19 therapeutics in plasma and paxlovid formulation using advanced multivariate modeling: a sustainability-centered bioanalytical approach. [PDF]

BMC Chem
Abbas AEF, Talib NFA, Elghobashy MR, Al Kamaly O, Halim MK.   +4 more
europepmc   +1 more source

A Box-Behnken design-assisted RP-HPLC method development and optimization for simultaneous determination of four antiviral drugs in pharmaceutical dosage forms. [PDF]

Sci Rep
Ghazy FH, El-Bagary RI, Fahim SH, Mahmoud ST.   +3 more
europepmc   +1 more source

Twenty Years of Dispersive Liquid-Liquid Microextraction: An Umbrella Review of Methodological Quality, Thematic Evolution, and Roadmap for Evidence Integration in Analytical Chemistry. [PDF]

Molecules
Faraji H, Conde Díaz A, Santana Mayor Á, Socas-Rodríguez B, Herrera Herrera AV.   +4 more
europepmc   +1 more source

Enabling Next-Generation Mass Spectrometry-Based Proteomics: Standards, Proteoform Resolution, and FAIR, Reproducible, and Quantitative Analysis. [PDF]

Proteomes
Vitorino R.
europepmc   +1 more source

A systematic review of predictors of college students' subjective well-being: evidence from pre- and post-pandemic literature. [PDF]

Front Public Health
He J, Rameli MRM.
europepmc   +1 more source

Quality by Design Approach for Hot-Melt Extrusion Coupled Fused Deposition Modeling (HME-FDM) 3D Printing: A Systematic Review. [PDF]

Pharmaceutics
Arany P, Papp Á, Nemes D, Fehér P, Ujhelyi Z, Bácskay I.   +5 more
europepmc   +1 more source