Results 231 to 240 of about 63,475,603 (280)

Quality by design in public healthcare: a rapid development framework for future pandemics. [PDF]

J Pharm Pharm Sci
Panda N, Maity M, Kotra V, Jena BR, Ghose D, Jena GS.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

AQbD-Based Development and Optimization of a Stability-Indicating RP-HPLC Method for Imeglimin With Integration of Lean Six Sigma Principles. [PDF]

Biomed Chromatogr
Bhusari VK, Ghorpade S, Sethy K.
europepmc   +1 more source

Quality by Design-Guided Transethosomal Gel of Donepezil Hydrochloride and Quercetin for Potential Alzheimer's Management: Stability-Indicating Eco-Compatible RP-HPLC Method. [PDF]

Drug Dev Res
Kumar A, Kaushik A, Devi A, Ankalgi AD, Ashawat MS, Alharbi HM, Amin M, Khojah AA, Ahmad S, Zaki MEA.   +9 more
europepmc   +1 more source

Self-Care Experiences of Individuals with Heart Failure: A Systematic Review and Metasynthesis. [PDF]

J Clin Med
Ahmad I, Bielecka-Dabrowa A, Subashi B, Chen Y.   +3 more
europepmc   +1 more source

Toward standardized continuous glucose monitoring validation: lessons from the Sinocare iCan i3 accuracy study. [PDF]

Front Clin Diabetes Healthc
Ameur A.
europepmc   +1 more source

An Integrated Quality by Design RP-UPLC Method for Lumacaftor and Ivacaftor in Human Plasma. [PDF]

Biomed Chromatogr
Jhampani S, Mounica RVS, Vidhyadhara S.
europepmc   +1 more source

Beyond the Numbers: Assessing Clinical Risk Associated with Significant Magnesium Assay Bias. [PDF]

Diagnostics (Basel)
Berihun M, Jaleta K, Adhikari S, Fankhauser K, Muthukumar A, Narasimhan M.   +5 more
europepmc   +1 more source

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A Complete Roadmap of Analytical Quality by Design in Various Analytical Techniques

Current Pharmaceutical Analysis, 2023
Background: For the development of robust analytical methods, Analytical-Qualityby- Design (AQbD)-based testing methods have been found to be more suited than other one factorial approaches. By creating a Method Operable Design Space, this strategy selects the optimal method conditions using the appropriate Design of Experiments.
Mohana Krishnan Santhanam, Nalini Calamur Nagarajan, Poorna Basuri Ponraj, Mohamed Sameer Mohamed Hilurudeen   +3 more
openaire   +3 more sources

Application of quality by design to the development of analytical separation methods

Analytical and Bioanalytical Chemistry, 2012
Recent pharmaceutical regulatory documents have stressed the critical importance of applying quality by design (QbD) principles for in-depth process understanding to ensure that product quality is built in by design. This article outlines the application of QbD concepts to the development of analytical separation methods, for example chromatography and
ORLANDINI, SERENA, PINZAUTI, SERGIO, FURLANETTO, SANDRA   +2 more
openaire   +5 more sources