Results 61 to 70 of about 63,340,489 (278)

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Quality-by-design-based development of ultradeformable nanovesiculartransgelosome of standardized Piper longum extract for melanoma - supplementary data

, 2023
Background: Melanoma is the most aggressive and deadly form of skin cancer. The stratum corneum of the skin is a major obstacle to dermal and transdermal drug delivery.
Dulla Naveen Kumar (16703779), Singh Shreya (16703780), Ashish Kumar Agrawal (16703784), Debadatta Mohapatra (11449636), Dhananjay Panigrahi (16703782), Alakh N Sahu (16703785)   +5 more
core   +1 more source

Quality by design-assisted green uv-spectrophotometric method development and validation for the quantitative estimation of letrozole

Drug Analytical Research
Letrozole, a potent aromatase inhibitor, is commonly used in treating hormone-responsive breast cancer. With the rising incidence of breast cancer and increased demand for anticancer agents, this study aims to develop a green, cost-effective, and ...
Shahrikh S. Pakali, Mahesh palled, Shailendra S. Suryawanshi   +2 more
doaj   +1 more source

Fluidised bed granulation of two APIs: QbD approach and development of a NIR in-line monitoring method

Asian Journal of Pharmaceutical Sciences, 2020
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale.
Alexandru Gavan, Sonia Iurian, Tibor Casian, Alina Porfire, Sebastian Porav, Ioana Voina, Alexandru Oprea, Ioan Tomuta   +7 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Eco-conscious AQbD-guided stability-indicating RP-UPLC method for analysing Tovorafenib in bulk and dosage forms

Scientific Reports
Tovorafenib is a type II RAF inhibitor recently approved by the FDA for relapsed or refractory paediatric low-grade glioma in children aged 6 months and older with BRAF fusions or V600E mutations, owing to its strong central nervous system penetration ...
Vanga Mohan Goud, Sarad Pawar Naik Bukke, Praveen Kumar Kusuma, Satla Shobha Rani, M. Sunitha Reddy, Chandrashekar Thalluri, Bayapa Reddy Narapureddy   +6 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

AQbD-enhanced green RP-UPLC-PDA methodology for quantification and forced degradation studies for omeprazole, amoxicillin, and rifabutin

BMC Chemistry
The ternary combination like omeprazole (OMP), amoxicillin (AMX), and rifabutin (RFB) was approved by the FDA in November 2019 for combating Helicobacter pylori infections and ulcers caused by this infection. This study aims to develop and authenticate a
S. P. Ashnah Baffinsha, Vijayageetha Ragupathi, Hemanth Kumar Chanduluru   +2 more
doaj   +1 more source

QbD assisted green and white analytical UPLC method quantification of pharmacopeia impurities of Pravastatin in bulk drug and pharmaceutical formulations

Journal of Applied Pharmaceutical Research
Background: A QbD-assisted green and white UPLC method was optimized for the simultaneous quantification of pravastatin and its EP impurities B, C, and D.
N. Usha Rani, P. T. S. R. K. Prasad Rao, K. Ramanjaneyulu   +2 more
doaj   +1 more source